Log-Contrast Regression with Functional Compositional Predictors: Linking Preterm Infant's Gut Microbiome Trajectories to Neurobehavioral Outcome

DOI10.1214/20-AOAS1357zbMATH Open1470.62167arXiv1808.02403OpenAlexW3088582118MaRDI QIDQ138028FDOQ138028

Authors: Zhe Sun, Wanli Xu, Xiaomei Cong, Gen Li, Kun Chen, Zhe Sun, Wanli Xu, Xiaomei Cong, Gen Li, Kun Chen 

Publication date: 7 August 2018

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Abstract: The neonatal intensive care unit (NICU) experience is known to be one of the most crucial factors that drive preterm infant's neurodevelopmental and health outcomes. It is hypothesized that stressful early life experience of very preterm neonate is imprinting gut microbiome by the regulation of the so-called brain-gut axis, and consequently, certain microbiome markers are predictive of later infant neurodevelopment. To investigate, a preterm infant study was conducted; infant fecal samples were collected during the infants' first month of postnatal age, resulting in functional compositional microbiome data, and neurobehavioral outcomes were measured when infants reached 36-38 weeks of post-menstrual age. To identify potential microbiome markers and estimate how the trajectories of gut microbiome compositions during early postnatal stage impact later neurobehavioral outcomes of the preterm infants, we innovate a sparse log-contrast regression with functional compositional predictors. The functional simplex structure is strictly preserved, and the functional compositional predictors are allowed to have sparse, smoothly varying, and accumulating effects on the outcome through time. Through a pragmatic basis expansion step, the problem boils down to a linearly constrained sparse group regression, for which we develop an efficient algorithm and obtain theoretical performance guarantees. Our approach yields insightful results in the preterm infant study. The identified microbiome markers and the estimated time dynamics of their impact on the neurobehavioral outcome shed light on the linkage between stress accumulation in early postnatal stage and neurodevelopmental process of infants.

Full work available at URL: https://arxiv.org/abs/1808.02403

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zbMATH Keywords

longitudinal dataconstrained optimizationgroup selectionsimplex

Mathematics Subject Classification ID

General nonlinear regression (62J02) Applications of statistics to biology and medical sciences; meta analysis (62P10) Applications of statistics to psychology (62P15) Functional data analysis (62R10)

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Cited In (7)

• A review of compositional data analysis and recent advances
• It's All Relative: Regression Analysis with Compositional Predictors
• Automatic nonnutritive suck waveform discrimination and feature extraction in preterm infants
• Multivariate log-contrast regression with sub-compositional predictors: testing the association between preterm infants' gut microbiome and neurobehavioral outcomes
• FDR control for linear log-contrast models with high-dimensional compositional covariates
• Compack
• Robust regression with compositional covariates

Uses Software

• R
• fda (R)

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