Cumulant dynamics of a population under multiplicative selection, mutation, and drift.

DOI10.1006/TPBI.2001.1531zbMATH Open1041.92019arXivadap-org/9907009OpenAlexW2090556895WikidataQ57660513 ScholiaQ57660513MaRDI QIDQ1427273FDOQ1427273

Authors: Magnus Rattray, Jonathan L. Shapiro 

Publication date: 14 March 2004

Published in: Theoretical Population Biology (Search for Journal in Brave)

Abstract: We revisit the classical population genetics model of a population evolving under multiplicative selection, mutation and drift. The number of beneficial alleles in a multi-locus system can be considered a trait under exponential selection. Equations of motion are derived for the cumulants of the trait distribution in the diffusion limit and under the assumption of linkage equilibrium. Because of the additive nature of cumulants, this reduces to the problem of determining equations of motion for the expected allele distribution cumulants at each locus. The cumulant equations form an infinite dimensional linear system and in an authored appendix Adam Prugel-Bennett provides a closed form expression for these equations. We derive approximate solutions which are shown to describe the dynamics well for a broad range of parameters. In particular, we introduce two approximate analytical solutions: (1) Perturbation theory is used to solve the dynamics for weak selection and arbitrary mutation rate. The resulting expansion for the system's eigenvalues reduces to the known diffusion theory results for the limiting cases with either mutation or selection absent. (2) For low mutation rates we observe a separation of time-scales between the slowest mode and the rest which allows us to develop an approximate analytical solution for the dominant slow mode. The solution is consistent with the perturbation theory result and provides a good approximation for much stronger selection intensities.

Full work available at URL: https://arxiv.org/abs/adap-org/9907009

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zbMATH Keywords

Fokker-Planck equationKolmogorov forward equation

Mathematics Subject Classification ID

Applications of Brownian motions and diffusion theory (population genetics, absorption problems, etc.) (60J70) Genetics and epigenetics (92D10) Problems related to evolution (92D15) Dynamical systems in biology (37N25)

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Cited In (10)

• Well posedness and maximum entropy approximation for the dynamics of quantitative traits
• Analytical solution of the evolution dynamics on a multiplicative-fitness landscape
• Evolutionary dynamics and eigenspectrum of confluent Heun equation
• On the application of statistical physics to evolutionary biology
• The many-demes limit for selection and drift in a subdivided population
• SYSTEMATIC APPROXIMATIONS FOR GENETIC DYNAMICS
• Evolving populations with overlapping generations
• When a genetic algorithm outperforms hill-climbing
• Exact solution of the multi-allelic diffusion model
• Cryptic selection forces and dynamic heritability in generalized phenotypic evolution

Uses Software

• Mathematica

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