Statistical learning formulation of the DNA base-calling problem and its solution in a Bayesian EM framework

DOI10.1016/S0166-218X(00)00192-XzbMath0969.92016OpenAlexW2013769445MaRDI QIDQ1585334

Barry L. Karger, Manuela S. Pereira, Lucio Andrade, Sameh El Difrawy, Elias S. Manolakos

Publication date: 6 November 2000

Published in: Discrete Applied Mathematics (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/s0166-218x(00)00192-x

zbMATH Keywords

algorithmschromosomessignal to noise ratioexpectation-maximization algorithmstatistical learningEMDNA base-calling

Mathematics Subject Classification ID

Bayesian inference (62F15) Biochemistry, molecular biology (92C40) Computational methods for problems pertaining to biology (92-08)

Related Items (2)

Robust normalization of DNA chromatograms by regression for improved base-calling ⋮ Basecalling using hidden Markov models

Uses Software

• BayesDA

Cites Work

• Statistical analysis of finite mixture distributions
• Application of expectation-maximization algorithm to the detection of a direct-sequence signal in pulsed noise jamming
• Maximum-likelihood localization of narrow-band autoregressive sources via the EM algorithm
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