Waiting time distributions for clusters of IP₃ receptors

DOI10.1016/J.JTBI.2009.03.018MaRDI QIDQ1624355zbMATH OpenOpenAlexWikidataFDO

Authors Erin R. Higgins, Heiko Schmidle, M. Falcke

Publication date 16 November 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2009.03.018

zbMATH Keywords

calcium dynamicsinositol 1,4,5-trisphosphate receptorion channels

Mathematics Subject Classification ID

Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Recommendations

• Modeling local and global intracellular calcium responses mediated by diffusely distributed inositol 1,4,5-trisphosphate receptors
• A kinetic Monte Carlo simulation study of inositol 1,4,5-trisphosphate receptor (IP3R) calcium release channel
• Extending the \(\mathrm{IP}_3\) receptor model to include competition with partial agonists
• The effect of residual \(\operatorname{Ca}^{2 +}\) on the stochastic gating of \(\operatorname{Ca}^{2 +} \)-regulated \(\operatorname{Ca}^{2 +}\) channel models
• Markov chain Monte Carlo fitting of single-channel data from inositol trisphosphate receptors

Cites work

• A stochastic automata network descriptor for Markov chain models of instantaneously coupled intracellular Ca\(^{2+}\) channels
• Identification of almost invariant aggregates in reversible nearly uncoupled Markov chains

Cited in

(3)

• Calsequestrin mediates changes in spontaneous calcium release profiles
• Mesoscopic behavior from microscopic Markov dynamics and its application to calcium release channels
• Extending the \(\mathrm{IP}_3\) receptor model to include competition with partial agonists

This page was built for publication: Waiting time distributions for clusters of IP\(_3\) receptors

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1624355)