Extending the IP₃ receptor model to include competition with partial agonists

DOI10.1016/J.JTBI.2012.06.011MaRDI QIDQ292755zbMATH OpenOpenAlexWikidataFDO

Authors Gregory Handy, Bradford E. Peercy

Publication date 9 June 2016

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2012.06.011

zbMATH Keywords

bifurcation diagramcalcium waveinositol-trisphosphate receptormathematical modelmulti-state model

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• Wave bifurcation and propagation failure in a model of Ca\(^{2+}\) release

Cited in

(3)

• Waiting time distributions for clusters of IP\(_3\) receptors
• Metabotropic receptor activation, desensitization and sequestration. I: Modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation
• A global model to define the behavior of partial agonists (bell-shaped dose-response inducers) in pharmacological evaluation of activity in the presence of the full agonist

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