Generalized concentration addition: a method for examining mixtures containing partial agonists

DOI10.1016/J.JTBI.2009.03.030MaRDI QIDQ1624432zbMATH OpenOpenAlexWikidataFDO

Authors Gregory J. Howard, Thomas F. Webster

Publication date 16 November 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL http://europepmc.org/articles/pmc2737481

zbMATH Keywords

additivityinteractionmixturessynergyTEF

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

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(6)

• A general formulation of the concept of independent action for the combined effects of agents
• A random effects model for binary mixture toxicity experiments
• Generalized concentration addition for ligands that bind to homodimers
• A global model to define the behavior of partial agonists (bell-shaped dose-response inducers) in pharmacological evaluation of activity in the presence of the full agonist
• Mathematical properties of Hand Incremental Effect Additivity and other synergy theories
• Incorporating biological knowledge in analyses of environmental mixtures and health

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