A testing based approach to the discovery of differentially correlated variable sets

DOI10.1214/17-AOAS1083zbMATH Open1405.62160OpenAlexW2963340803WikidataQ92219804 ScholiaQ92219804MaRDI QIDQ1624840FDOQ1624840

Authors Y. Aharonov

Publication date 16 November 2018

Published in The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1509.08124

zbMATH Keywords

high-dimensional datagenomicsbiostatisticsassociation miningdifferential correlation mining

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Measures of association (correlation, canonical correlation, etc.) (62H20) Protein sequences, DNA sequences (92D20) Biomedical imaging and signal processing (92C55)

Abstract: Given data obtained under two sampling conditions, it is often of interest to identify variables that behave differently in one condition than in the other. We introduce a method for differential analysis of second-order behavior called Differential Correlation Mining (DCM). The DCM method identifies differentially correlated sets of variables, with the property that the average pairwise correlation between variables in a set is higher under one sample condition than the other. DCM is based on an iterative search procedure that adaptively updates the size and elements of a candidate variable set. Updates are performed via hypothesis testing of individual variables, based on the asymptotic distribution of their average differential correlation. We investigate the performance of DCM by applying it to simulated data as well as recent experimental datasets in genomics and brain imaging.

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Cited in

(2)

• EdgeMarker: identifying differentially correlated molecule pairs as edge-biomarkers
• Test for high-dimensional correlation matrices

Describes a project that uses

Uses Software

• WGCNA
• ESSC
• FAMT
• Diffcorr
• DCGL
• DNA
• DiffCoEx
• PRMLT

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