Optimal therapy scheduling based on a pair of collaterally sensitive drugs

DOI10.1101/196824MaRDI QIDQ1670458zbMATH OpenOpenAlexWikidataFDO

Authors Nara Yoon, Robert Vander Velde, Andriy Marusyk, Jacob G. Scott

Publication date 5 September 2018

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1101/196824

zbMATH Keywords

cancerdynamical systemsoptimal controlevolution of resistance

Mathematics Subject Classification ID

Medical applications (general) (92C50) Applications of optimal control and differential games (49N90)

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Cites work

• A mathematical model to study the effects of drug resistance and vasculature on the response of solid tumors to chemotherapy
• A model for the resistance of tumor cells to cancer chemotherapeutic agents
• A single-cell approach in modeling the dynamics of tumor microregions
• An elementary approach to modeling drug resistance in cancer
• Optimal policies of non-cross-resistant chemotherapy on Goldie and Coldman's cancer model
• The application of mathematical modelling to aspects of adjuvant chemotherapy scheduling
• The influence of toxicity constraints in models of chemotherapeutic protocol escalation
• The mathematical modelling of adjuvant chemotherapy scheduling: incorporating the effects of protocol rest phases and pharmacokinetics
• The worst drug rule revisited: mathematical modeling of cyclic cancer treatments

Cited in

(6)

• The impact of competition between cancer cells and healthy cells on optimal drug delivery
• Scheduling collateral sensitivity‐based cycling therapies toward eradication of drug‐resistant infections
• Theoretical modeling of collaterally sensitive drug cycles: shaping heterogeneity to allow adaptive therapy
• Modelling bistable tumour population dynamics to design effective treatment strategies
• The worst drug rule revisited: mathematical modeling of cyclic cancer treatments
• Inferring density-dependent population dynamics mechanisms through rate disambiguation for logistic birth-death processes

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