Mathematical modelling of the interaction between cancer cells and an oncolytic virus: insights into the effects of treatment protocols
From MaRDI portal
Publication:1670482
Abstract: Oncolytic virotherapy is an experimental cancer treatment that uses genetically engineered viruses to target and kill cancer cells. One major limitation of this treatment is that virus particles are rapidly cleared by the immune system, preventing them from arriving at the tumour site. To improve virus survival and infectivity modified virus particles with the polymer polyethylene glycol (PEG) and the monoclonal antibody herceptin. While PEG modification appeared to improve plasma retention and initial infectivity it also increased the virus particle arrival time. We derive a mathematical model that describes the interaction between tumour cells and an oncolytic virus. We tune our model to represent the experimental data by Kim et al. (2011) and obtain optimised parameters. Our model provides a platform from which predictions may be made about the response of cancer growth to other treatment protocols beyond those in the experiments. Through model simulations we find that the treatment protocol affects the outcome dramatically. We quantify the effects of dosage strategy as a function of tumour cell replication and tumour carrying capacity on the outcome of oncolytic virotherapy as a treatment. The relative significance of the modification of the virus and the crucial role it plays in optimising treatment efficacy is explored.
Recommendations
- scientific article; zbMATH DE number 6720796
- Oncolytic virus treatment of human breast cancer cells: modelling therapy efficacy
- The role of viral infectivity in oncolytic virotherapy outcomes: a mathematical study
- A mathematical model for the role of macrophages in the persistence and elimination of oncolytic viruses
- Analysis of a mathematical model for tumor therapy with a fusogenic oncolytic virus
Cited in
(42)- Oncolytic virotherapy for tumours following a Gompertz growth law
- A mathematical model for tumor growth and treatment using virotherapy
- Application of control theory in a delayed-infection and immune-evading oncolytic virotherapy
- Slow-fast model and therapy optimization for oncolytic treatment of tumors
- On a mathematical model of tumor-immune system interactions with an oncolytic virus therapy
- Hopf bifurcation analysis of a tumor virotherapy model with two time delays
- Population dynamics with threshold effects give rise to a diverse family of Allee effects
- A mathematical model for oncolytic virus spread using the telegraph equation
- On the treatment of melanoma: a mathematical model of oncolytic virotherapy
- scientific article; zbMATH DE number 6720796 (Why is no real title available?)
- Multiscale modelling of cancer response to oncolytic viral therapy
- A mathematical model of viral oncology as an immuno-oncology instigator
- The role of viral infectivity in oncolytic virotherapy outcomes: a mathematical study
- Agent-based and continuum models for spatial dynamics of infection by oncolytic viruses
- Computational modeling of cancer response to oncolytic virotherapy: improving the effectiveness of viral spread and anti tumor efficacy
- Enhancing oncolytic virotherapy: observations from a Voronoi cell-based model
- Stability analysis of a fractional virotherapy model for cancer treatment
- Mathematical model of optimal chemotherapy and oncolytic virotherapy
- Multiscale moving boundary modelling of cancer interactions with a fusogenic oncolytic virus: the impact of syncytia dynamics
- Computational modeling approaches to studying the dynamics of oncolytic viruses
- A fractional mathematical model of breast cancer competition model
- Oscillations in a spatial oncolytic virus model
- On the dynamics and optimal control of a mathematical model of neuroblastoma and its treatment: insights from a mathematical model
- A combination therapy of oncolytic viruses and chimeric antigen receptor T cells: a mathematical model proof-of-concept
- Analysis of a mathematical model for tumor therapy with a fusogenic oncolytic virus
- A cellular automata model of oncolytic virotherapy in pancreatic cancer
- Modelling heterogeneity in viral-tumour dynamics: the effects of gene-attenuation on viral characteristics
- Mathematical modelling of a hypoxia-regulated oncolytic virus delivered by tumour-associated macrophages
- Oncolytic virus treatment of human breast cancer cells: modelling therapy efficacy
- A mathematical model for the role of macrophages in the persistence and elimination of oncolytic viruses
- Bistability in a model of tumor-immune system interactions with an oncolytic viral therapy
- scientific article; zbMATH DE number 5044737 (Why is no real title available?)
- Modeling the virus-induced tumor-specific immune response with delay in tumor virotherapy
- Spatial cumulant models enable spatially informed treatment strategies and analysis of local interactions in cancer systems
- Model-driven approaches for in vitro combination therapy using ONYX-015 replicating oncolytic adenovirus
- Developing a minimally structured mathematical model of cancer treatment with oncolytic viruses and dendritic cell injections
- Non-local multiscale approaches for tumour-oncolytic viruses interactions
- Quantitative impact of immunomodulation versus oncolysis with cytokine-expressing virus therapeutics
- Modeling oncolytic virotherapy: is complete tumor-tropism too much of a good thing?
- Effects of CCN1 and macrophage content on glioma virotherapy: a mathematical model
- A mathematical model of combined therapies against cancer using viruses and inhibitors
- Oscillation thresholds via the novel MBR method with application to oncolytic virotherapy
This page was built for publication: Mathematical modelling of the interaction between cancer cells and an oncolytic virus: insights into the effects of treatment protocols
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1670482)
