The role of viral infectivity in oncolytic virotherapy outcomes: a mathematical study

DOI10.1016/J.MBS.2020.108520MaRDI QIDQ2240252zbMATHOpenAlexWikidataFDO

Authors Pantea Pooladvand, Chae-Ok Yun, A.-Rum Yoon, Federico Frascoli, Peter S. Kim

Publication date 8 November 2021

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2110.03357

zbMATH Keywords

bifurcation theoryODEsoncolytic virotherapyPDEs

Mathematics Subject Classification ID

Medical applications (general) (92C50) Bifurcation theory for ordinary differential equations (34C23) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Abstract: A model capturing the dynamics between virus and tumour cells in the context of oncolytic virotherapy is presented and analysed. The ability of the virus to be internalised by uninfected cells is described by an infectivity parameter, which is inferred from available experimental data. The parameter is also able to describe the effects of changes in the tumour environment that affect viral uptake from tumour cells. Results show that when a virus is inoculated inside a growing tumour, strategies for enhancing infectivity do not lead to a complete eradication of the tumour. Within typical times of experiments and treatments, we observe the onset of oscillations, which always prevent a full destruction of the tumour mass. These findings are in good agreement with available laboratory results. Further analysis shows why a fully successful therapy cannot exist for the proposed model and that care must be taken when designing and engineering viral vectors with enhanced features. In particular, bifurcation analysis reveals that creating longer lasting virus particles or using strategies for reducing infected cell lifespan can cause unexpected and unwanted surges in the overall tumour load over time. Our findings suggest that virotherapy alone seems unlikely to be effective in clinical settings unless adjuvant strategies are included.

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Cites work

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Cited in

(21)

• Oncolytic virotherapy for tumours following a Gompertz growth law
• Dynamics of tumor virotherapy: a deterministic and stochastic model approach
• On the treatment of melanoma: a mathematical model of oncolytic virotherapy
• scientific article; zbMATH DE number 6720796 (Why is no real title available?)
• A mathematical model of viral oncology as an immuno-oncology instigator
• Agent-based and continuum models for spatial dynamics of infection by oncolytic viruses
• Enhancing oncolytic virotherapy: observations from a Voronoi cell-based model
• The replicability of oncolytic virus: defining conditions in tumor virotherapy
• Oncolytic viral therapies and the delicate balance between virus-macrophage-tumour interactions: a mathematical approach
• Oscillations in a spatial oncolytic virus model
• A combination therapy of oncolytic viruses and chimeric antigen receptor T cells: a mathematical model proof-of-concept
• Modelling heterogeneity in viral-tumour dynamics: the effects of gene-attenuation on viral characteristics
• Oncolytic virus treatment of human breast cancer cells: modelling therapy efficacy
• A mathematical model for the role of macrophages in the persistence and elimination of oncolytic viruses
• The role of the innate immune system in oncolytic virotherapy
• Quantitative impact of immunomodulation versus oncolysis with cytokine-expressing virus therapeutics
• Modeling oncolytic virotherapy: is complete tumor-tropism too much of a good thing?
• Resistance in oncolytic viral therapy for solid tumors
• Finding Hopf bifurcation islands and identifying thresholds for success or failure in oncolytic viral therapy
• Mathematical modelling of the interaction between cancer cells and an oncolytic virus: insights into the effects of treatment protocols
• Oscillation thresholds via the novel MBR method with application to oncolytic virotherapy

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