The role of viral infectivity in oncolytic virotherapy outcomes: a mathematical study

DOI10.1016/J.MBS.2020.108520zbMATH Open1475.92087arXiv2110.03357OpenAlexW3112837402WikidataQ104130389 ScholiaQ104130389MaRDI QIDQ2240252FDOQ2240252

Authors: Pantea Pooladvand, Chae-Ok Yun, A.-Rum Yoon, Federico Frascoli, Peter S. Kim 

Publication date: 8 November 2021

Published in: Mathematical Biosciences (Search for Journal in Brave)

Abstract: A model capturing the dynamics between virus and tumour cells in the context of oncolytic virotherapy is presented and analysed. The ability of the virus to be internalised by uninfected cells is described by an infectivity parameter, which is inferred from available experimental data. The parameter is also able to describe the effects of changes in the tumour environment that affect viral uptake from tumour cells. Results show that when a virus is inoculated inside a growing tumour, strategies for enhancing infectivity do not lead to a complete eradication of the tumour. Within typical times of experiments and treatments, we observe the onset of oscillations, which always prevent a full destruction of the tumour mass. These findings are in good agreement with available laboratory results. Further analysis shows why a fully successful therapy cannot exist for the proposed model and that care must be taken when designing and engineering viral vectors with enhanced features. In particular, bifurcation analysis reveals that creating longer lasting virus particles or using strategies for reducing infected cell lifespan can cause unexpected and unwanted surges in the overall tumour load over time. Our findings suggest that virotherapy alone seems unlikely to be effective in clinical settings unless adjuvant strategies are included.

Full work available at URL: https://arxiv.org/abs/2110.03357

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zbMATH Keywords

bifurcation theoryODEsoncolytic virotherapyPDEs

Mathematics Subject Classification ID

Medical applications (general) (92C50) Bifurcation theory for ordinary differential equations (34C23) PDEs in connection with biology, chemistry and other natural sciences (35Q92)

Cites Work

• ODE models for oncolytic virus dynamics
• Modeling and analysis of a virus that replicates selectively in tumor cells
• Enhancing oncolytic virotherapy: observations from a Voronoi cell-based model
• Modeling of cancer virotherapy with recombinant measles viruses
• Modelling the spatiotemporal dynamics of chemovirotherapy cancer treatment
• The role of the innate immune system in oncolytic virotherapy
• The replicability of oncolytic virus: defining conditions in tumor virotherapy
• Oncolytic virotherapy for tumours following a Gompertz growth law

Cited In (9)

• Title not available (Why is that?)
• A mathematical model of viral oncology as an immuno-oncology instigator
• Oscillations in a spatial oncolytic virus model
• Oscillation thresholds via the novel MBR method with application to oncolytic virotherapy
• The replicability of oncolytic virus: defining conditions in tumor virotherapy
• Finding Hopf bifurcation islands and identifying thresholds for success or failure in oncolytic viral therapy
• A combination therapy of oncolytic viruses and chimeric antigen receptor T cells: a mathematical model proof-of-concept
• Oncolytic virus treatment of human breast cancer cells: modelling therapy efficacy
• Agent-based and continuum models for spatial dynamics of infection by oncolytic viruses

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