Statistical modelling of higher-order correlations in pools of neural activity

DOI10.1016/J.PHYSA.2013.03.012zbMATH Open1395.92043arXiv1211.6348OpenAlexW2056431926MaRDI QIDQ1673015FDOQ1673015

Authors: Fernando Montani, Elena Phoka, M. Portesi, Simon R. Schultz 

Publication date: 11 September 2018

Published in: Physica A (Search for Journal in Brave)

Abstract: Simultaneous recordings from multiple neural units allow us to investigate the activity of very large neural ensembles. To understand how large ensembles of neurons process sensory information, it is necessary to develop suitable statistical models to describe the response variability of the recorded spike trains. Using the information geometry framework, it is possible to estimate higher-order correlations by assigning one interaction parameter to each degree of correlation, leading to a $(2^N-1)$-dimensional model for a population with $N$ neurons. However, this model suffers greatly from a combinatorial explosion, and the number of parameters to be estimated from the available sample size constitutes the main intractability reason of this approach. To quantify the extent of higher than pairwise spike correlations in pools of multiunit activity, we use an information-geometric approach within the framework of the extended central limit theorem considering all possible contributions from high-order spike correlations. The identification of a deformation parameter allows us to provide a statistical characterisation of the amount of high-order correlations in the case of a very large neural ensemble, significantly reducing the number of parameters, avoiding the sampling problem, and inferring the underlying dynamical properties of the network within pools of multiunit neural activity.

Full work available at URL: https://arxiv.org/abs/1211.6348

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zbMATH Keywords

information geometryextended central limit theoremlarge neural ensemblemultiunit neural activity

Mathematics Subject Classification ID

Parametric inference (62F99) Neural biology (92C20) Statistical thermodynamics (82B30)

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Cited In (10)

• Investigation of Possible Neural Architectures Underlying Information-Geometric Measures
• A path integral approach to the Hodgkin-Huxley model
• Higher-order correlations in common input shapes the output spiking activity of a neural population
• Theory of population coupling and applications to describe high order correlations in large populations of interacting neurons
• The population tracking model: a simple, scalable statistical model for neural population data
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• Analysis of higher-order neuronal interactions based on conditional inference
• The Costs of Ignoring High-Order Correlations in Populations of Model Neurons
• Causal information quantification of prominent dynamical features of biological neurons
• Modeling the correlated activity of neural populations: a review

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