Normal and pathological dynamics of platelets in humans
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Publication:1679007
DOI10.1007/S00285-017-1125-6zbMATH Open1380.37146arXiv1608.02806OpenAlexW2482880671WikidataQ33440808 ScholiaQ33440808MaRDI QIDQ1679007FDOQ1679007
Authors: Gabriel P. Langlois, Morgan Craig, M. C. Mackey, Joseph M. Mahaffy, Jacques Bélair, Thibault Moulin, Sean R. Sinclair, L. Wang, A. R. Humphries 
Publication date: 8 November 2017
Published in: Journal of Mathematical Biology (Search for Journal in Brave)
Abstract: We develop a comprehensive mathematical model of platelet, megakaryocyte, and thrombopoietin dynamics in humans. We show that there is a single stationary solution that can undergo a Hopf bifurcation, and use this information to investigate both normal and pathological platelet production, specifically cyclic thrombocytopenia. Carefully estimating model parameters from laboratory and clinical data, we then argue that a subset of parameters are involved in the genesis of cyclic thrombocytopenia based on clinical information. We provide excellent model fits to the existing data for both platelet counts and thrombopoietin levels by changing six parameters that have physiological correlates. Our results indicate that the primary change in cyclic thrombocytopenia is a major interference with or destruction of the thrombopoietin receptor with secondary changes in other processes, including immune-mediated destruction of platelets and megakaryocyte deficiency and failure in platelet production. This study makes a major contribution to the understanding of the origin of cyclic thrombopoietin as well as significantly extending the modeling of thrombopoiesis.
Full work available at URL: https://arxiv.org/abs/1608.02806
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delay differential equationcyclic thrombocytopeniadynamic diseasemegakaryopoiesisplatelet regulation dynamicsthrombopoiesis
Medical applications (general) (92C50) Dynamical systems in biology (37N25) Physiology (general) (92C30) Physiological flow (92C35)
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Cited In (21)
- Modelling thrombopoiesis regulation. II: Mathematical investigation of the model
- Distributed delay differential equation representations of cyclic differential equations
- Response of an oscillatory differential delay equation to a periodic stimulus
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- A biomathematical model of human thrombopoiesis under chemotherapy
- Origins of oscillation patterns in cyclical thrombocytopenia
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