Mixed analytical-stochastic simulation method for the recovery of a Brownian gradient source from probability fluxes to small windows
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Publication:1700871
Abstract: Is it possible to recover the position of a source from the steady-state fluxes of Brownian particles to small absorbing windows located on the boundary of a domain? To address this question, we develop a numerical procedure to avoid tracking Brownian trajectories in the entire infinite space. Instead, we generate particles near the absorbing windows, computed from the analytical expression of the exit probability. When the Brownian particles are generated by a steady-state gradient at a single point, we compute asymptotically the fluxes to small absorbing holes distributed on the boundary of half-space and on a disk in two dimensions, which agree with stochastic simulations. We also derive an expression for the splitting probability between small windows using the matched asymptotic method. Finally, when there are more than two small absorbing windows, we show how to reconstruct the position of the source from the diffusion fluxes. The present approach provides a computational first principle for the mechanism of sensing a gradient of diffusing particles, a ubiquitous problem in cell biology.
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Cites work
- Asymptotic analysis of first passage time problems inspired by ecology
- Conditional mean first passage times to small traps in a 3-D domain with a sticky boundary: applications to T cell searching behavior in lymph nodes
- Connecting a Discrete Ionic Simulation to a Continuum
- Diffusion escape through a cluster of small absorbing windows
- First Passage Statistics for the Capture of a Brownian Particle by a Structured Spherical Target with Multiple Surface Traps
- Green's functions. Construction and applications
- Know the single-receptor sensing limit? Think again
- Modeling homeoprotein intercellular transfer unveils a parsimonious mechanism for gradient and boundary formation in early brain development
- Stochastic narrow escape in molecular and cellular biology
- Summing Logarithmic Expansions for Singularly Perturbed Eigenvalue Problems
- The narrow escape problem
- The stationary arrival process of independent diffusers from a continuum to an absorbing boundary is Poissonian
- Theory and applications of stochastic processes. An analytical approach
- Time scale of diffusion in molecular and cellular biology
Cited in
(4)- Monte Carlo tracking drift-diffusion trajectories algorithm for solving narrow escape problems
- Trapping of Planar Brownian Motion: Full First Passage Time Distributions by Kinetic Monte Carlo, Asymptotic, and Boundary Integral Methods
- Reconstructing a point source from diffusion fluxes to narrow windows in three dimensions
- Stochastic simulation algorithms for solving narrow escape diffusion problems by introducing a drift to the target
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