General theory for stochastic admixture graphs and F-statistics

DOI10.1016/J.TPB.2018.12.002MaRDI QIDQ1714236zbMATH OpenOpenAlexWikidataFDO

Authors Samuele Soraggi, Carsten Wiuf

Publication date 31 January 2019

Published in Theoretical Population Biology (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1807.07593

zbMATH Keywords

Wright-Fisher modelgenetic driftintrogression\(F\)-statisticheterozygosityMarkov graphical model

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Applications of graph theory (05C90) Genetics and epigenetics (92D10) Problems related to evolution (92D15)

Abstract: We provide a general mathematical framework based on the theory of graphical models to study admixture graphs. Admixture graphs are used to describe the ancestral relationships between past and present populations, allowing for population merges and migration events, by means of gene flow. We give various mathematical properties of admixture graphs with particular focus on properties of the so-called $F$-statistics. Also the Wright-Fisher model is studied and a general expression for the loss of heterozygosity is derived.

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Cited in

(7)

• On the heterozygosity of an admixed population
• Mathematical properties of \(F_{\mathrm{st}}\) between admixed populations and their parental source populations
• Inference on admixture fractions in a mechanistic model of recurrent admixture
• A geometrical framework for \(f\)-statistics
• Developments in coalescent theory from single loci to chromosomes
• Understanding admixture fractions: theory and estimation of gene-flow
• Topological signatures for population admixture

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