Regulation of tumour intracellular pH: a mathematical model examining the interplay between H^+ and lactate

DOI10.1016/J.JTBI.2013.01.007MaRDI QIDQ1715210zbMATH OpenOpenAlexWikidataFDO

Authors Maymona Al-Husari, Steven D. Webb

Publication date 4 February 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2013.01.007

zbMATH Keywords

modellinglactate/H\(^+\) symporterNa\(^+\)/H\(^+\) antiporterpH gradienttumour microenvironment

Mathematics Subject Classification ID

Medical applications (general) (92C50) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• Mathematical model of pulsed immunotherapy for superficial bladder cancer
• Mathematical modelling of cancer cell invasion of tissue: local and non-local models and the effect of adhesion
• Necrotic core in EMT6/Ro tumour spheroids: is it caused by an ATP deficit?
• The role of acidity in solid tumour growth and invasion

Cited in

(6)

• A mathematical model for the glucose-lactate metabolism of in vitro cancer cells
• A mathematical model of tumour and blood pHe regulation: the \(\mathrm{HCO}^-_3/\mathrm{CO}_2\) buffering system
• A cellular automaton model examining the effects of oxygen, hydrogen ions and lactate on early tumour growth
• Glucose-lactate metabolic cooperation in cancer: insights from a spatial mathematical model and implications for targeted therapy
• Physiological insights into electrodiffusive maintenance of gastric mucus through sensitivity analysis and simulations
• Modelling acidosis and the cell cycle in multicellular tumour spheroids

Describes a project that uses

Uses Software

• Matlab

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