Distinguishing graded and ultrasensitive signalling cascade kinetics by the shape of morphogen gradients in \textit{Drosophila}

DOI10.1016/J.JTBI.2011.06.012MaRDI QIDQ1786084zbMATH OpenOpenAlexWikidataFDO

Authors S. MacNamara, Ruth E. Baker, Philip K. Maini

Publication date 24 September 2018

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2011.06.012

zbMATH Keywords

mitogen-activated-protein kinase

Mathematics Subject Classification ID

Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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(3)

• Stability of regulatory protein gradients induced by morphogen Dpp in \textit{Drosophila} wing disc
• An asymptotic analysis of intracellular signaling gradients arising from multiple small compart\-ments
• Signal propagation of the MAPK cascade in Xenopus oocytes: role of bistability and ultrasensitivity for a mixed problem

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