Robustness of morphogen gradients with ``bucket brigade transport through membrane-associated non-receptors
The paper is devoted to a mathematical analysis of a model of morphogen gradient formation in the presence of non-receptors with both diffusion of free morphogens and the movement of morphogens bound to non-receptors. A functional boundary value problem is introduced and existence, uniqueness and linear stability of a biologically acceptable steady-state solution is proven. The robustness of this steady-state solution with respect to significant changes in the morphogen synthesis rate is analyzed. It is proven that the model is able to produce robust biological morphogen gradients when production and degradation rates of morphogens are large enough and non-receptors are abundant. The results in this paper provide mathematical and biological insight to a mechanism of achieving stable robust long distance morphogen gradients.
- Mathematical model of the formation of morphogen gradients through membrane-associated non-receptors
- Cell-surface bound nonreceptors and signaling morphogen gradients
- Membrane-associated non-receptors and morphogen gradients
- Mathematical models of receptor-mediated transport of morphogens
- Morphogen gradient with expansion-repression mechanism: steady-state and robustness studies
- mRNA diffusion explains protein gradients in \textit{Drosophila} early development
- Distinguishing graded and ultrasensitive signalling cascade kinetics by the shape of morphogen gradients in \textit{Drosophila}
- Modeling morphogen gradient formation from arbitrary realistically shaped sources
- Model for the robust establishment of precise proportions in the early \textit{Drosophila} embryo
- Fast-tracking morphogen diffusion
- Membrane-associated non-receptors and morphogen gradients
- Morphogenetic gradients and the stability of boundaries between neighboring morphogenetic regions
- Morphogen gradient with expansion-repression mechanism: steady-state and robustness studies
- Spatially distributed morphogen production and morphogen gradient formation
- On the spread of morphogens
- Effects of tissue growth on robust formation of morphogen gradient
- Cell-surface bound nonreceptors and signaling morphogen gradients
- A new approach to feedback for robust signaling gradients
- Mathematical analysis on a multidimensional model of morphogen transport with receptor synthesis
- Mathematical models of receptor-mediated transport of morphogens
- Blowup properties for several diffusion systems with localised sources
- Nonlinear Eigenvalue Problems in the Stability Analysis of Morphogen Gradients
- Aggregation of a Distributed Source in Morphogen Gradient Formation
- Local accumulation times of morphogen gradient with tissue growth
- Robustness of signaling gradient in drosophila wing imaginal disc
- The scaling and shift of morphogen gene expression boundary in a nonlinear reaction diffusion system
- Internalization and end flux in morphogen gradient formation
- The mechanism of sudden stripe formation during dorso-ventral patterning in Drosophila
This page was built for publication: Robustness of morphogen gradients with ``bucket brigade transport through membrane-associated non-receptors
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1948824)
