How quantitative measures unravel design principles in multi-stage phosphorylation cascades

DOI10.1016/j.jtbi.2008.04.037zbMath1400.92183OpenAlexW1982043127WikidataQ57261282 ScholiaQ57261282MaRDI QIDQ1797393

Thomas Millat, Simone Frey, Olaf Wolkenhauer, Stefan Hohmann

Publication date: 22 October 2018

Published in: Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1016/j.jtbi.2008.04.037

zbMATH Keywords

structural analysisamplificationMAPK-pathwaymulti-stage phosphorylation cascadesmultiple phosphorylationphosphatase ratequantitative measuresweak activation

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40) Cell biology (92C37)

Related Items (2)

Bifurcations and chaos in the MAPK signaling cascade ⋮ Integration of sensitivity and bifurcation analysis to detect critical processes in a model combining signalling and cell population dynamics

Cites Work

• Optimal phosphorylation step number of intracellular signal-transduction pathway
• Approximations and their consequences for dynamic modelling of signal transduction pathways
• How robust are switches in intracellular signaling cascades?

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