Bifurcations and chaos in the MAPK signaling cascade

DOI10.1016/J.JTBI.2010.04.025MaRDI QIDQ1720107zbMATH OpenOpenAlexWikidataFDO

Authors Martin Zumsande, Thilo Gross

Publication date 12 February 2019

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2010.04.025

zbMATH Keywords

modelingbistabilityphosphorylationsignaling networks

Mathematics Subject Classification ID

Cell biology (92C37) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• scientific article; zbMATH DE number 50395 (Why is no real title available?)
• COMPUTATION AND VISUALIZATION OF BIFURCATION SURFACES
• Elements of applied bifurcation theory
• Evidence of chaos in eco-epidemic models
• How quantitative measures unravel design principles in multi-stage phosphorylation cascades
• Solving Nonlinear Equations with Newton's Method
• Stabilization due to predator interference: comparison of different analysis approaches

Cited in

(15)

• Sustained oscillations in the MAP kinase cascade
• Amplification and oscillations in the FAK/Src kinase system during integrin signaling
• Mesoscale symmetries explain dynamical equivalence of food webs
• Stochastic bifurcation for a tumor-immune system with symmetric Lévy noise
• Identifying the parametric occurrence of multiple steady states for some biological networks
• Structural properties of the MAPK pathway topologies in PC12 cells
• Evolution of complex probability distributions in enzyme cascades
• New trends and perspectives in nonlinear intracellular dynamics: one century from Michaelis-Menten paper
• Non-equilibrium thermodynamics of biological signal transduction predicts conservation of entropy production rate
• Generalized modeling of empirical social-ecological systems
• Signal propagation of the MAPK cascade in Xenopus oocytes: role of bistability and ultrasensitivity for a mixed problem
• Stochastic bifurcation in single-species model induced by α-stable Lévy noise
• On Nonlinear Dynamics of the STAT5a Signaling Protein
• A proof of bistability for the dual futile cycle
• Revealing instabilities in a generalized triadic supply network: a bifurcation analysis

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Uses Software

• RODAS

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