A proof of bistability for the dual futile cycle

DOI10.1016/j.nonrwa.2015.02.004zbMath1331.34089arXiv1404.0394OpenAlexW2963135937MaRDI QIDQ892271

Juliette Hell, Alan D. Rendall

Publication date: 18 November 2015

Published in: Nonlinear Analysis. Real World Applications (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1404.0394

zbMATH Keywords

bistabilitygeometric singular perturbation theorycusp bifurcationMAPkinase cascademultiple futile cycle

Mathematics Subject Classification ID

Topological structure of integral curves, singular points, limit cycles of ordinary differential equations (34C05) Bifurcation theory for ordinary differential equations (34C23) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Cell biology (92C37) Qualitative investigation and simulation of ordinary differential equation models (34C60) Singular perturbations for ordinary differential equations (34E15)

Related Items (15)

The kinetic space of multistationarity in dual phosphorylation ⋮ Stability analysis of the Michaelis-Menten approximation of a mixed mechanism of a phosphorylation system ⋮ Stability of stationary solutions in models of the Calvin cycle ⋮ Sustained oscillations in the MAP kinase cascade ⋮ Addition of flow reactions preserving multistationarity and bistability ⋮ An all-encompassing global convergence result for processive multisite phosphorylation systems ⋮ Emergence of oscillations in a mixed-mechanism phosphorylation system ⋮ Structural Conditions for Saddle-Node Bifurcations in Chemical Reaction Networks ⋮ A proof of unlimited multistability for phosphorylation cycles ⋮ Algebra and Geometry in the Study of Enzymatic Cascades ⋮ Precluding oscillations in Michaelis-Menten approximations of dual-site phosphorylation systems ⋮ Parameter regions that give rise to \(2\lfloor \frac{n}{2} \rfloor +1\) positive steady states in the \(n\)-site phosphorylation system ⋮ On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle ⋮ Symbolic Proof of Bistability in Reaction Networks ⋮ A global convergence result for processive multisite phosphorylation systems

Cites Work

• Unnamed Item
• \(n\)-site phosphorylation systems with \(2n-1\) steady states
• On the number of steady states in a multiple futile cycle
• Singularly perturbed monotone systems and an Application to double phosphorylation cycles
• Nonlinear oscillations, dynamical systems, and bifurcations of vector fields
• Applications of centre manifold theory
• Geometric singular perturbation theory for ordinary differential equations
• Bifurcations and chaos in the MAPK signaling cascade
• Translation-invariant monotone systems, and a global convergence result for enzymatic futile cycles
• Singular Perturbations on the Infinite Interval

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