A global convergence result for processive multisite phosphorylation systems
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Publication:2352437
DOI10.1007/S11538-014-0054-4zbMATH Open1334.92169arXiv1404.5524OpenAlexW2135846414WikidataQ50987140 ScholiaQ50987140MaRDI QIDQ2352437FDOQ2352437
Authors: Carsten Conradi, Anne Shiu 
Publication date: 1 July 2015
Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)
Abstract: Multisite phosphorylation plays an important role in intracellular signaling. There has been much recent work aimed at understanding the dynamics of such systems when the phosphorylation/dephosphorylation mechanism is distributive, that is, when the binding of a substrate and an enzyme molecule results in addition or removal of a single phosphate group and repeated binding therefore is required for multisite phosphorylation. In particular, such systems admit bistability. Here we analyze a different class of multisite systems, in which the binding of a substrate and an enzyme molecule results in addition or removal of phosphate groups at all phosphorylation sites. That is, we consider systems in which the mechanism is processive, rather than distributive. We show that in contrast with distributive systems, processive systems modeled with mass-action kinetics do not admit bistability and, moreover, exhibit rigid dynamics: each invariant set contains a unique equilibrium, which is a global attractor. Additionally, we obtain a monomial parametrization of the steady states. Our proofs rely on a technique of Johnston for using "translated" networks to study systems with "toric steady states", recently given sign conditions for injectivity of polynomial maps, and a result from monotone systems theory due to Angeli and Sontag.
Full work available at URL: https://arxiv.org/abs/1404.5524
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global convergencesteady statemonotone systemsmass-action kineticsreaction networkmultisite phosphorylationmonomial parametrization
Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)
Cites Work
- Title not available (Why is that?)
- A Petri net approach to the study of persistence in chemical reaction networks
- Chemical reaction systems with toric steady states
- Title not available (Why is that?)
- Graph-theoretic characterizations of monotonicity of chemical networks in reaction coordinates
- Multiple steady states for chemical reaction networks of deficiency one
- The rational parameterisation theorem for multisite post-translational modification systems
- Global Asymptotic Stability for a Class of Nonlinear Chemical Equations
- Sign conditions for injectivity of generalized polynomial maps with applications to chemical reaction networks and real algebraic geometry
- Some results on injectivity and multistationarity in chemical reaction networks
- Local and global stability of equilibria for a class of chemical reaction networks
- A proof of bistability for the dual futile cycle
- A geometric approach to the global attractor conjecture
- On the number of steady states in a multiple futile cycle
- Multistationarity in the activation of a MAPK: parametrizing the relevant region in parameter space
- Concordant chemical reaction networks
- Global convergence in systems of differential equations arising from chemical reaction networks
- Graph-theoretic approaches to injectivity and multiple equilibria in systems of interacting elements
- Monotonicity in chemical reaction systems
- Translation-invariant monotone systems, and a global convergence result for enzymatic futile cycles
- Multistationarity in sequential distributed multisite phosphorylation networks
- Translated chemical reaction networks
- \(n\)-site phosphorylation systems with \(2n-1\) steady states
- Power-law kinetics and determinant criteria for the preclusion of multistationarity in networks of interacting species
- MAPK's networks and their capacity for multistationarity due to toric steady states
- Simplifying the Jacobian criterion for precluding multistationarity in chemical reaction networks
- Frequency spectra and probability distributions for quantum fluctuations
Cited In (26)
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- Complexity of model testing for dynamical systems with toric steady states
- Bifunctional enzyme provides absolute concentration robustness in multisite covalent modification networks
- In distributive phosphorylation catalytic constants enable non-trivial dynamics
- Diffusion modifies the connectivity of kinetic schemes for multisite binding and catalysis
- Algebra and geometry in the study of enzymatic cascades
- An all-encompassing global convergence result for processive multisite phosphorylation systems
- Oscillations and bistability in a model of ERK regulation
- Families of toric chemical reaction networks
- Dynamics of ERK regulation in the processive limit
- On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle
- \(n\)-site phosphorylation systems with \(2n-1\) steady states
- Sustained oscillations in the MAP kinase cascade
- A computational approach to steady state correspondence of regular and generalized mass action systems
- Chemical reaction network approaches to biochemical systems theory
- A computational approach to persistence, permanence, and endotacticity of biochemical reaction systems
- Lower bounds for positive roots and regions of multistationarity in chemical reaction networks
- Emergence of oscillations in a mixed-mechanism phosphorylation system
- The effect of site-to-site variability in ultrasensitive dose responses
- Intermediates and generic convergence to equilibria
- Computing weakly reversible deficiency zero network translations using elementary flux modes
- Global stability of a class of futile cycles
- Precluding oscillations in Michaelis-Menten approximations of dual-site phosphorylation systems
- A proof of unlimited multistability for phosphorylation cycles
- Multistationarity in sequential distributed multisite phosphorylation networks
- Algebra, geometry and topology of ERK kinetics
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