Precluding oscillations in Michaelis-Menten approximations of dual-site phosphorylation systems
From MaRDI portal
Publication:669100
DOI10.1016/J.MBS.2018.10.008zbMATH Open1409.92108arXiv1712.03594OpenAlexW2773192016WikidataQ58546664 ScholiaQ58546664MaRDI QIDQ669100FDOQ669100
Authors: Hwai-Ray Tung 
Publication date: 20 March 2019
Published in: Mathematical Biosciences (Search for Journal in Brave)
Abstract: Oscillations play a major role in a number of biological systems, from predator-prey models of ecology to circadian clocks. In this paper we focus on the question of whether oscillations exist within dual-site phosphorylation systems. Previously, Wang and Sontag showed, using monotone systems theory, that the Michaelis-Menten (MM) approximation of the distributive and sequential dual-site phosphorylation system lacks oscillations. However, biological systems are generally not purely distributive; there is generally some processive behavior as well. Accordingly, this paper focuses on the MM approximation of a general sequential dual-site phosphorylation system that contains both processive and distributive components, termed the composite system. Expanding on the methods of Bozeman and Morales, we preclude oscillations in the MM approximation of the composite system. This implies the lack of oscillations in the MM approximations of the processive and distributive systems, shown previously, as well as in the MM approximation of the partially processive and partially distributive mixed-mechanism system.
Full work available at URL: https://arxiv.org/abs/1712.03594
Recommendations
- Stability analysis of the Michaelis-Menten approximation of a mixed mechanism of a phosphorylation system
- Emergence of oscillations in a mixed-mechanism phosphorylation system
- On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle
- Dynamics of ERK regulation in the processive limit
- Oscillations and bistability in a model of ERK regulation
Cites Work
- A proof of bistability for the dual futile cycle
- A global convergence result for processive multisite phosphorylation systems
- Global stability of a class of futile cycles
- Singularly perturbed monotone systems and an Application to double phosphorylation cycles
- Stability analysis of the Michaelis-Menten approximation of a mixed mechanism of a phosphorylation system
- An all-encompassing global convergence result for processive multisite phosphorylation systems
Cited In (7)
- Stability analysis of the Michaelis-Menten approximation of a mixed mechanism of a phosphorylation system
- The kinetic space of multistationarity in dual phosphorylation
- On the stability of a class of Michaelis-Menten networks
- Dynamics of ERK regulation in the processive limit
- On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle
- Emergence of oscillations in a mixed-mechanism phosphorylation system
- Oscillatory dynamics arising from competitive inhibition and multisite phosphorylation
This page was built for publication: Precluding oscillations in Michaelis-Menten approximations of dual-site phosphorylation systems
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q669100)
