On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle

DOI10.3934/MBE.2020027zbMATH Open1470.92116arXiv1905.08129OpenAlexW2945634363WikidataQ91298294 ScholiaQ91298294MaRDI QIDQ2045703FDOQ2045703

Authors: Carsten Conradi, Elisenda Feliu, Maya Mincheva 

Publication date: 13 August 2021

Published in: Mathematical Biosciences and Engineering (Search for Journal in Brave)

Abstract: Protein phosphorylation cycles are important mechanisms of the post translational modification of a protein and as such an integral part of intracellular signaling and control. We consider the sequential phosphorylation and dephosphorylation of a protein at two binding sites. While it is known that proteins where phosphorylation is processive and dephosphorylation is distributive admit oscillations (for some value of the rate constants and total concentrations) it is not known whether or not this is the case if both phosphorylation and dephosphorylation are distributive. We study four simplified mass action models of sequential and distributive phosphorylation and show that for each of those there do not exist rate constants and total concentrations where a Hopf bifurcation occurs. To arrive at this result we use convex parameters to parameterize the steady state and Hurwitz matrices.

Full work available at URL: https://arxiv.org/abs/1905.08129

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zbMATH Keywords

Hopf bifurcationoscillationschemical reaction networksconvex parametersphosphorylation networks

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Bifurcation theory for ordinary differential equations (34C23)

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Cited In (10)

• In distributive phosphorylation catalytic constants enable non-trivial dynamics
• The kinetic space of multistationarity in dual phosphorylation
• Dynamics of ERK regulation in the processive limit
• Connectivity of parameter regions of multistationarity for multisite phosphorylation networks
• Effect of binding in cyclic phosphorylation\,--\,dephosphorylation process and in energy transfor\-ma\-tion
• Local and global robustness at steady state
• Emergence of oscillations in a mixed-mechanism phosphorylation system
• Hopf Bifurcations of Reaction Networks with Zero-One Stoichiometric Coefficients
• Precluding oscillations in Michaelis-Menten approximations of dual-site phosphorylation systems
• A proof of unlimited multistability for phosphorylation cycles

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