On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle
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Publication:2045703
Abstract: Protein phosphorylation cycles are important mechanisms of the post translational modification of a protein and as such an integral part of intracellular signaling and control. We consider the sequential phosphorylation and dephosphorylation of a protein at two binding sites. While it is known that proteins where phosphorylation is processive and dephosphorylation is distributive admit oscillations (for some value of the rate constants and total concentrations) it is not known whether or not this is the case if both phosphorylation and dephosphorylation are distributive. We study four simplified mass action models of sequential and distributive phosphorylation and show that for each of those there do not exist rate constants and total concentrations where a Hopf bifurcation occurs. To arrive at this result we use convex parameters to parameterize the steady state and Hurwitz matrices.
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Cites work
- A global convergence result for processive multisite phosphorylation systems
- A proof of bistability for the dual futile cycle
- Classical quasi-steady state reduction -- a mathematical characterization
- Convex Analysis
- Criterion of Hopf bifurcations without using eigenvalues
- Deciding Hopf bifurcations by quantifier elimination in a software-component architecture
- Detection of Hopf bifurcations in chemical reaction networks using convex coordinates
- Determining ``small parameters for quasi-steady state
- Elements of applied bifurcation theory
- Emergence of oscillations in a mixed-mechanism phosphorylation system
- Generalized form of Hurwitz-Routh criterion and Hopf bifurcation of higher order
- Inheritance of oscillation in chemical reaction networks
- Multistationarity in the activation of a MAPK: parametrizing the relevant region in parameter space
- On the number of steady states in a multiple futile cycle
- Oscillations and bistability in a model of ERK regulation
- Precluding oscillations in Michaelis-Menten approximations of dual-site phosphorylation systems
- Switching in Mass Action Networks Based on Linear Inequalities
- The multistationarity structure of networks with intermediates and a binomial core network
- Toric ideals and graph theory to analyze Hopf bifurcations in mass action systems
- \(n\)-site phosphorylation systems with \(2n-1\) steady states
Cited in
(10)- In distributive phosphorylation catalytic constants enable non-trivial dynamics
- The kinetic space of multistationarity in dual phosphorylation
- Dynamics of ERK regulation in the processive limit
- Effect of binding in cyclic phosphorylation\,--\,dephosphorylation process and in energy transfor\-ma\-tion
- Connectivity of parameter regions of multistationarity for multisite phosphorylation networks
- Local and global robustness at steady state
- Emergence of oscillations in a mixed-mechanism phosphorylation system
- Hopf Bifurcations of Reaction Networks with Zero-One Stoichiometric Coefficients
- Precluding oscillations in Michaelis-Menten approximations of dual-site phosphorylation systems
- A proof of unlimited multistability for phosphorylation cycles
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