The multistationarity structure of networks with intermediates and a binomial core network

DOI10.1007/S11538-019-00612-1zbMATH Open1417.92058arXiv1808.07548OpenAlexW3106191959WikidataQ92127672 ScholiaQ92127672MaRDI QIDQ2002118FDOQ2002118

AmirHosein Sadeghimanesh, Elisenda Feliu

Publication date: 11 July 2019

Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)

Abstract: This work addresses whether a reaction network, taken with mass-action kinetics, is multistationary, that is, admits more than one positive steady state in some stoichiometric compatibility class. We build on previous work on the effect that removing or adding intermediates has on multistationarity, and also on methods to detect multistationarity for networks with a binomial steady state ideal. In particular, we provide a new determinant criterion to decide whether a network is multistationary, which applies when the network obtained by removing intermediates has a binomial steady state ideal. We apply this method to easily characterize which subsets of complexes are responsible for multistationarity; this is what we call the emph{multistationarity structure} of the network. We use our approach to compute the multistationarity structure of the $n$-site sequential distributive phosphorylation cycle for arbitrary n.

Full work available at URL: https://arxiv.org/abs/1808.07548

zbMATH Keywords

toric idealmodel reductionbinomial idealmultistationaritydeterminant criterionphosphorylation cycle

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

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Cited In (16)

• Families of polynomials in the study of biochemical reaction networks
• Testing binomiality of chemical reaction networks using comprehensive Gröbner systems
• Multistationarity questions in reduced versus extended biochemical networks
• Multistationarity in the space of total concentrations for systems that admit a monomial parametrization
• Parameter regions that give rise to \(2\lfloor \frac{n}{2} \rfloor +1\) positive steady states in the \(n\)-site phosphorylation system
• Oscillations and bistability in a model of ERK regulation
• Families of toric chemical reaction networks
• Bistability of sequestration networks
• Dynamics of ERK regulation in the processive limit
• Kac-Rice formulas and the number of solutions of parametrized systems of polynomial equations
• On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle
• Multiperiod medians on networks
• Algebra and Geometry in the Study of Enzymatic Cascades
• Title not available (Why is that?)
• Symbolic Proof of Bistability in Reaction Networks
• Multistationarity in structured reaction networks

Uses Software

• MESSI

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