The multistationarity structure of networks with intermediates and a binomial core network
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Publication:2002118
DOI10.1007/S11538-019-00612-1zbMATH Open1417.92058arXiv1808.07548OpenAlexW3106191959WikidataQ92127672 ScholiaQ92127672MaRDI QIDQ2002118FDOQ2002118
Authors: AmirHosein Sadeghimanesh, Elisenda Feliu 
Publication date: 11 July 2019
Published in: Bulletin of Mathematical Biology (Search for Journal in Brave)
Abstract: This work addresses whether a reaction network, taken with mass-action kinetics, is multistationary, that is, admits more than one positive steady state in some stoichiometric compatibility class. We build on previous work on the effect that removing or adding intermediates has on multistationarity, and also on methods to detect multistationarity for networks with a binomial steady state ideal. In particular, we provide a new determinant criterion to decide whether a network is multistationary, which applies when the network obtained by removing intermediates has a binomial steady state ideal. We apply this method to easily characterize which subsets of complexes are responsible for multistationarity; this is what we call the emph{multistationarity structure} of the network. We use our approach to compute the multistationarity structure of the -site sequential distributive phosphorylation cycle for arbitrary n.
Full work available at URL: https://arxiv.org/abs/1808.07548
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Cited In (19)
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