Dynamics of ERK regulation in the processive limit
From MaRDI portal
Publication:2661971
Abstract: We consider a model of extracellular signal-regulated kinase (ERK) regulation by dual-site phosphorylation and dephosphorylation, which exhibits bistability and oscillations, but loses these properties in the limit in which the mechanisms underlying phosphorylation and dephosphorylation become processive. Our results suggest that anywhere along the way to becoming processive, the model remains bistable and oscillatory. More precisely, in simplified versions of the model, precursors to bistability and oscillations (specifically, multistationarity and Hopf bifurcations, respectively) exist at all "processivity levels". Finally, we investigate whether bistability and oscillations can exist together.
Recommendations
- Oscillations and bistability in a model of ERK regulation
- A global convergence result for processive multisite phosphorylation systems
- Oscillatory dynamics arising from competitive inhibition and multisite phosphorylation
- On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle
- Precluding oscillations in Michaelis-Menten approximations of dual-site phosphorylation systems
Cites work
- A global convergence result for processive multisite phosphorylation systems
- Addition of flow reactions preserving multistationarity and bistability
- Atoms of multistationarity in chemical reaction networks
- Elements of applied bifurcation theory
- Emergence of oscillations in a mixed-mechanism phosphorylation system
- Generalized form of Hurwitz-Routh criterion and Hopf bifurcation of higher order
- HomotopyContinuation.jl: a package for homotopy continuation in Julia
- Ideals, varieties, and algorithms. An introduction to computational algebraic geometry and commutative algebra
- Inheritance of oscillation in chemical reaction networks
- Multistationarity in structured reaction networks
- On the existence of Hopf bifurcations in the sequential and distributive double phosphorylation cycle
- On the number of steady states in a multiple futile cycle
- Oscillations and bistability in a model of ERK regulation
- Parameter regions that give rise to \(2\lfloor \frac{n}{2} \rfloor +1\) positive steady states in the \(n\)-site phosphorylation system
- Power-law kinetics and determinant criteria for the preclusion of multistationarity in networks of interacting species
- Structure and stability of certain chemical networks and applications to the kinetic proofreading model of T-cell receptor signal transduction
- Sustained oscillations in the MAP kinase cascade
- The inheritance of nondegenerate multistationarity in chemical reaction networks
- The multistationarity structure of networks with intermediates and a binomial core network
Cited in
(7)- Regulation of kinase activity by diffusion and feedback
- Structural instability in an autophosphorylating kinase switch
- Oscillations and bistability in a model of ERK regulation
- A kinetic model of ERK cyclic pathway on substrate control
- Splitting Reactions Preserves Nondegenerate Behaviors in Chemical Reaction Networks
- Absolute concentration robustness: algebra and geometry
- Precluding oscillations in Michaelis-Menten approximations of dual-site phosphorylation systems
This page was built for publication: Dynamics of ERK regulation in the processive limit
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q2661971)
