Hopf Bifurcations of Reaction Networks with Zero-One Stoichiometric Coefficients

DOI10.1137/22M1519754MaRDI QIDQ6076409zbMATH OpenOpenAlexFDO

Authors Xiaoxian Tang

Publication date 21 September 2023

Published in SIAM Journal on Applied Dynamical Systems (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/2208.04196

zbMATH Keywords

Hopf bifurcationoscillationmass-action kineticsbiochemical reaction network

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Bifurcation theory for ordinary differential equations (34C23) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Abstract: For the reaction networks with zero-one stoichiometric coefficients (or simply zero-one networks), we prove that if a network admits a Hopf bifurcation, then the rank of the stoichiometric matrix is at least four. As a corollary, we show that if a zero-one network admits a Hopf bifurcation, then it contains at least four species and five reactions. As applications, we show that there exist rank-four subnetworks, which have the capacity for Hopf bifurcations/oscillations, in two biologically significant networks: the MAPK cascades and the ERK network. We provide a computational tool for computing all four-species, five-reaction, zero-one networks that have the capacity for Hopf bifurcations.

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Cited in

(8)

• scientific article; zbMATH DE number 1160683 (Why is no real title available?)
• Combinatorial approaches to Hopf bifurcations in systems of interacting elements
• Classification of infinitesimal homeostasis in four-node input-output networks
• Efficient methods to compute Hopf bifurcations in chemical reaction networks using reaction coordinates
• The smallest bimolecular mass action reaction networks admitting Andronov–Hopf bifurcation
• Prevalence of Multistationarity and Absolute Concentration Robustness in Reaction Networks
• Detection of Hopf bifurcations in chemical reaction networks using convex coordinates
• Symbolic Proof of Bistability in Reaction Networks

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