Sustained oscillations in the MAP kinase cascade

DOI10.1016/J.MBS.2016.10.011MaRDI QIDQ343085zbMATH OpenOpenAlexWikidataFDO

Authors Juliette Hell, Alan D. Rendall

Publication date 21 November 2016

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1509.02667

zbMATH Keywords

dynamical systemsHopf bifurcationgeometric singular perturbation theorychemical reaction networkMAP kinase cascade

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Bifurcation theory for ordinary differential equations (34C23) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Abstract: The MAP kinase cascade is a network of enzymatic reactions arranged in layers. In each layer occurs a multiple futile cycle of phosphorylations. The fully phosphorylated substrate then serves as an enzyme for the layer below. This papers focusses on the existence of parameters for which Hopf bifurcations occur and generate periodic orbits. Furthermore it is explained how geometric singular perturbation theory allows to generalize results from simple models to more complex ones.

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Cites work

• scientific article; zbMATH DE number 3138903 (Why is no real title available?)
• scientific article; zbMATH DE number 42093 (Why is no real title available?)
• scientific article; zbMATH DE number 3297399 (Why is no real title available?)
• A global convergence result for processive multisite phosphorylation systems
• A proof of bistability for the dual futile cycle
• Bifurcations and chaos in the MAPK signaling cascade
• Geometric singular perturbation theory for ordinary differential equations
• On the number of steady states in a multiple futile cycle
• Oscillations in monotone systems with a negative feedback
• Oscillations in multi-stable monotone systems with slowly varying feedback

Cited in

(14)

• The smallest bimolecular mass action reaction networks admitting Andronov–Hopf bifurcation
• On the Liouville integrability of Edelstein's reaction system in R^3
• Splitting Reactions Preserves Nondegenerate Behaviors in Chemical Reaction Networks
• Algebra and geometry in the study of enzymatic cascades
• The kinetic space of multistationarity in dual phosphorylation
• Oscillations and bistability in a model of ERK regulation
• Dynamics of ERK regulation in the processive limit
• A proof of bistability for the dual futile cycle
• Structural properties of the MAPK pathway topologies in PC12 cells
• Emergence of oscillations in a mixed-mechanism phosphorylation system
• Oscillatory dynamics arising from competitive inhibition and multisite phosphorylation
• Signal propagation of the MAPK cascade in Xenopus oocytes: role of bistability and ultrasensitivity for a mixed problem
• Bifurcations and chaos in the MAPK signaling cascade
• A proof of unlimited multistability for phosphorylation cycles

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