Sustained oscillations in the MAP kinase cascade

DOI10.1016/J.MBS.2016.10.011zbMATH Open1352.92072arXiv1509.02667OpenAlexW2963106084WikidataQ50532352 ScholiaQ50532352MaRDI QIDQ343085FDOQ343085

Juliette Hell, Alan D. Rendall

Publication date: 21 November 2016

Published in: Mathematical Biosciences (Search for Journal in Brave)

Abstract: The MAP kinase cascade is a network of enzymatic reactions arranged in layers. In each layer occurs a multiple futile cycle of phosphorylations. The fully phosphorylated substrate then serves as an enzyme for the layer below. This papers focusses on the existence of parameters for which Hopf bifurcations occur and generate periodic orbits. Furthermore it is explained how geometric singular perturbation theory allows to generalize results from simple models to more complex ones.

Full work available at URL: https://arxiv.org/abs/1509.02667

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zbMATH Keywords

dynamical systemsHopf bifurcationgeometric singular perturbation theorychemical reaction networkMAP kinase cascade

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40) Bifurcation theory for ordinary differential equations (34C23) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Cites Work

• Title not available (Why is that?)
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• Geometric singular perturbation theory for ordinary differential equations
• A proof of bistability for the dual futile cycle
• Bifurcations and chaos in the MAPK signaling cascade
• A global convergence result for processive multisite phosphorylation systems
• Oscillations in multi-stable monotone systems with slowly varying feedback
• Oscillations in Monotone Systems with a Negative Feedback
• On the number of steady states in a multiple futile cycle

Cited In (9)

• The smallest bimolecular mass action reaction networks admitting Andronov–Hopf bifurcation
• Splitting Reactions Preserves Nondegenerate Behaviors in Chemical Reaction Networks
• On the Liouville integrability of Edelstein's reaction system in \(\mathbb R^3\)
• The kinetic space of multistationarity in dual phosphorylation
• Oscillations and bistability in a model of ERK regulation
• Dynamics of ERK regulation in the processive limit
• Algebra and Geometry in the Study of Enzymatic Cascades
• Oscillatory dynamics arising from competitive inhibition and multisite phosphorylation
• A proof of unlimited multistability for phosphorylation cycles

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