Bifunctional enzyme provides absolute concentration robustness in multisite covalent modification networks

DOI10.1007/s00285-024-02060-5arXiv2304.02679OpenAlexW4392391661MaRDI QIDQ6149820

Tung D. Nguyen, Badal Joshi

Publication date: 5 March 2024

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/2304.02679

zbMATH Keywords

bifunctional enzymefutile cycleabsolute concentration robustnesscovalent modification networkparadoxical enzyme

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40) Systems biology, networks (92C42)

Cites Work

• On the number of steady states in a multiple futile cycle
• Foundations of chemical reaction network theory
• The rational parameterisation theorem for multisite post-translational modification systems
• Network translation and steady-state properties of chemical reaction systems
• Foundations of static and dynamic absolute concentration robustness
• A global convergence result for processive multisite phosphorylation systems
• Reciprocal enzyme regulation as a source of bistability in covalent modification cycles
• Prevalence of deficiency-zero reaction networks in an Erdös–Rényi framework
• Power-Engine-Load Form for Dynamic Absolute Concentration Robustness
• Reaction Network Motifs for Static and Dynamic Absolute Concentration Robustness

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