Prevalence of deficiency-zero reaction networks in an Erdős-Rényi framework

DOI10.1017/JPR.2021.65MaRDI QIDQ5086997zbMATH OpenOpenAlexFDO

Authors Tung D. Nguyen, David F. Anderson

Publication date 8 July 2022

Published in Journal of Applied Probability (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1910.12723

zbMATH Keywords

random graphthreshold functiondeficiencyreaction networkErdős-Rényi

Mathematics Subject Classification ID

Applications of graph theory (05C90) Random graphs (graph-theoretic aspects) (05C80) Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Abstract: Reaction networks are commonly used within the mathematical biology and mathematical chemistry communities to model the dynamics of interacting species. These models differ from the typical graphs found in random graph theory since their vertices are constructed from elementary building blocks, i.e., the species. In this paper, we consider these networks in an ErdH os-R'enyi framework and, under suitable assumptions, derive a threshold function for the network to have a deficiency of zero, which is a property of great interest in the reaction network community. Specifically, if the number of species is denoted by $n$ and if the edge probability is denote by $p_n$, then we prove that the probability of a random binary network being deficiency zero converges to 1 if $frac{p}_{n}r(n)o0$, as $noinfty$, and converges to 0 if $frac{p}_{n}r(n)oinfty$, as $noinfty$, where $r(n)=frac1n^3$.

Recommendations

• Deficiency zero for random reaction networks under a stochastic block model framework
• Foundations of chemical reaction network theory
• The existence and uniqueness of steady states for a class of chemical reaction networks
• Parametric uniqueness of deficiency zero reaction networks
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Cites work

• A geometric approach to the global attractor conjecture
• An ecological framework for the analysis of prebiotic chemical reaction networks
• Deficiency zero for random reaction networks under a stochastic block model framework
• Finite Time Distributions of Stochastically Modeled Chemical Systems with Absolute Concentration Robustness
• Large deviations theory for Markov jump models of chemical reaction networks
• On the geometry of chemical reaction networks: Lyapunov function and large deviations
• Product-form Poisson-like distributions and complex balanced reaction systems
• Product-form stationary distributions for deficiency zero chemical reaction networks
• Product-form stationary distributions for deficiency zero networks with non-mass action kinetics
• Results on stochastic reaction networks with non-mass action kinetics
• The average distances in random graphs with given expected degrees
• Threshold functions

Cited in

(5)

• Bifunctional enzyme provides absolute concentration robustness in multisite covalent modification networks
• Prevalence of Multistationarity and Absolute Concentration Robustness in Reaction Networks
• Computational Translation Framework Identifies Biochemical Reaction Networks with Special Topologies and Their Long-Term Dynamics
• Polyhedral geometry and combinatorics of an autocatalytic ecosystem
• Deficiency zero for random reaction networks under a stochastic block model framework

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