Structural identifiability and indistinguishability of certain two- compartment models incorporating nonlinear efflux from the peripheral compartment

DOI10.1016/0025-5564(94)00023-SMaRDI QIDQ1804848zbMATH OpenOpenAlexWikidataFDO

Authors Michael J. Chappell

Publication date 27 September 1995

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/0025-5564(94)00023-s

zbMATH Keywords

compartmental modelsHill equationnonlinear effluxperipheral compartmentreceptor sitessimilarity transformation approachstructural identifiabilitysubstance inputtwo-compartment model

Mathematics Subject Classification ID

General biology and biomathematics (92B05) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) System identification (93B30)

Review text

The structural identifiability of three similar compartmental models is considered where each system incorporates a different form of nonlinear efflux from a peripheral compartment. The concept of physiological or pharmacological effect is incorporated in these models in the sense that the ``effect of the substance input is governed by its presence on receptor sites within the system [see \textit{J. G. Wagner}, J. Theor. Biol. 20, 173-201 (1968)]. Such presence is in turn determined by the systems' kinetics or the form of the nonlinearity employed. The indistinguishability of these three systems is also examined using the recent results provided by \textit{M. J. Chapman} et al. [Math. Biosci. 119, No. 1, 77-95 (1994; Zbl 0817.92001)] for parametrized nonlinear systems.

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Cites work

• A methodology for compartmental model indistinguishability
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• scientific article; zbMATH DE number 3924604 (Why is no real title available?)
• scientific article; zbMATH DE number 42093 (Why is no real title available?)
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Cited in

(6)

• A procedure for generating locally identifiable reparametrisations of unidentifiable nonlinear systems by the similarity transformation approach
• Indistinguishability for a class of nonlinear compartmental models
• A decomposition method for solving nonlinear systems of compartment models
• The solution of a two-compartment model
• Modeling antibiotic resistance in pregnant woman and fetus
• Similarity transformation approach to identifiability analysis of nonlinear compartmental models

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