Incorporating phenotype-dependent growth rates into the color-shift model for preneoplastic hepatocellular lesions

DOI10.1016/S0025-5564(02)00107-4MaRDI QIDQ1866974zbMATH OpenWikidataFDO

Authors Iris Burkholder, Annette Kopp-Schneider

Publication date 2 April 2003

Published in Mathematical Biosciences (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/S0025-5564(02)00107-4

zbMATH Keywords

color-shift modelepigenetic eventshepatocarcinogenesismulti-stage modelpreneoplastic liver lesions

Mathematics Subject Classification ID

Signal detection and filtering (aspects of stochastic processes) (60G35) Medical applications (general) (92C50)

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Cites work

• A model for hepatocarcinogenesis treating phenotypical changes in focal hepatocellular lesions as epigenetic events
• A model for hepatocarcinogenesis with clonal expansion of three successive phenotypes of preneoplastic cells
• Are Two Mutations Sufficient to Cause Cancer? Some Generalizations of the Two-Mutation Model of Carcinogenesis of Moolgavkar, Venzon, and Knudson, and of the Multistage Model of Armitage and Doll

Cited in

(5)

• A model for hepatocarcinogenesis treating phenotypical changes in focal hepatocellular lesions as epigenetic events
• A model for hepatocarcinogenesis with clonal expansion of three successive phenotypes of preneoplastic cells
• Application of a color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment
• Using a stochastic model to analyze the sequence of phenotypic changes in rat liver focal lesions
• Application of a two-phenotype color-shift model with heterogeneous growth to a rat hepatocarcinogenesis experiment

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