A model for hepatocarcinogenesis treating phenotypical changes in focal hepatocellular lesions as epigenetic events

DOI10.1016/S0025-5564(97)10007-4zbMath0953.92020WikidataQ52242444 ScholiaQ52242444MaRDI QIDQ1306986

Annette Kopp-Schneider, P. Bannasch, Christopher J. Portier

Publication date: 29 January 2001

Published in: Mathematical Biosciences (Search for Journal in Brave)

zbMATH Keywords

likelihood; birth and death process; multistage model; focal liver lesion; stochastic carcinogenesis model

Mathematics Subject Classification ID

62P10: Applications of statistics to biology and medical sciences; meta analysis

60J85: Applications of branching processes

92C50: Medical applications (general)

92C37: Cell biology

60J80: Branching processes (Galton-Watson, birth-and-death, etc.)

Related Items

Using a stochastic model to analyze the sequence of phenotypic changes in rat liver focal lesions, A model for hepatocarcinogenesis with clonal expansion of three successive phenotypes of preneoplastic cells, Incorporating phenotype-dependent growth rates into the color-shift model for preneoplastic hepatocellular lesions

Cites Work

• Unnamed Item
• Unnamed Item
• The application of a multistage model that incorporates DNA damage and repair to the analysis of initiation/promotion experiments
• Two-event models for carcinogenesis: Incidence curves for childhood and adult tumors
• Birth-death processes with piecewise constant rates
• A stem cell model for carcinogenesis
• Birth-and-death processes, and the theory of carcinogenesis