Coagulation-fragmentation for a finite number of particles and application to telomere clustering in the yeast nucleus

DOI10.1016/J.PHYSLETA.2012.01.014MaRDI QIDQ1933197zbMATH OpenOpenAlexWikidataFDO

Authors N. Hoze, D. Holcman

Publication date 22 January 2013

Published in Physics Letters. A (Search for Journal in Brave)

Full work available at URL https://arxiv.org/abs/1201.2620

Mathematics Subject Classification ID

Biochemistry, molecular biology (92C40)

Abstract: We develop a coagulation-fragmentation model to study a system composed of a small number of stochastic objects moving in a confined domain, that can aggregate upon binding to form local clusters of arbitrary sizes. A cluster can also dissociate into two subclusters with a uniform probability. To study the statistics of clusters, we combine a Markov chain analysis with a partition number approach. Interestingly, we obtain explicit formulas for the size and the number of clusters in terms of hypergeometric functions. Finally, we apply our analysis to study the statistical physics of telomeres (ends of chromosomes) clustering in the yeast nucleus and show that the diffusion-coagulation-fragmentation process can predict the organization of telomeres.

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Cites work

• scientific article; zbMATH DE number 3814037 (Why is no real title available?)
• A guide to first-passage processes
• Combinatorial stochastic processes. Ecole d'Eté de Probabilités de Saint-Flour XXXII -- 2002.
• The equilibrium behavior of reversible coagulation-fragmentation processes
• Theory and applications of stochastic processes. An analytical approach

Cited in

(7)

• 100 years after Smoluchowski: stochastic processes in cell biology
• Stochastic coagulation-fragmentation processes with a finite number of particles and applications
• Coagulation-fragmentation with a finite number of particles: models, stochastic analysis, and applications to telomere clustering and viral capsid assembly
• Polymer physics of nuclear organization and function
• Modeling capsid kinetics assembly from the steady state distribution of multi-sizes aggregates
• Kinetics of aggregation with a finite number of particles and application to viral capsid assembly
• Deterministic and Stochastic Becker–Döring Equations: Past and Recent Mathematical Developments

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