Efficient computation with a linear mixed model on large-scale data sets with applications to genetic studies

DOI10.1214/12-AOAS586zbMath1454.62377arXiv1207.4886OpenAlexW3102205410WikidataQ57612017 ScholiaQ57612017MaRDI QIDQ1951539

Matti Pirinen, Peter Donnelly, Chris C. A. Spencer

Publication date: 6 June 2013

Published in: The Annals of Applied Statistics (Search for Journal in Brave)

Full work available at URL: https://arxiv.org/abs/1207.4886

zbMATH Keywords

case-control studylinear mixed modelgenetic association study

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Genetics and epigenetics (92D10)

Related Items (5)

Heritability estimation in case-control studies ⋮ Heritability estimation in high dimensional sparse linear mixed models ⋮ Statistical properties of simple random-effects models for genetic heritability ⋮ Efficient computation with a linear mixed model on large-scale data sets with applications to genetic studies ⋮ Gene-Based Association Testing of Dichotomous Traits With Generalized Functional Linear Mixed Models Using Extended Pedigrees: Applications to Age-Related Macular Degeneration

Uses Software

• GenABEL
• TASSEL

Cites Work

• Unnamed Item
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• Likelihood, Bayesian, and MCMC methods in quantitative genetics
• Population structure and cryptic relatedness in genetic association studies
• Genomic control, a new approach to genetic-based association studies.
• Efficient computation with a linear mixed model on large-scale data sets with applications to genetic studies
• Bayes Factors

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