A schistosomiasis model with praziquantel resistance

DOI10.1155/2013/945767MaRDI QIDQ1956142zbMATH OpenOpenAlexWikidataFDO

Authors Longxing Qi, Jing-An Cui

Publication date 13 June 2013

Published in Discrete Dynamics in Nature and Society (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2013/945767

Mathematics Subject Classification ID

Qualitative investigation and simulation of models involving functional-differential equations (34K60) Dynamical systems in biology (37N25) Epidemiology (92D30)

Review text

Summary: A compartmental model is established for schistosomiasis with praziquantel resistance. The model considers the impact of genetic resistance and drug treatment on the transmission of schistosomiasis. We calculate the basic reproductive number and discuss the existence and stability of disease-free equilibrium, boundary equilibrium, and coexistence equilibrium. Our analysis shows that regardless of whether drug treatment leads to the emergence of resistance, once the impact of genetic resistance is larger, the resistant strain will be dominant, which is detrimental to the control of schistosomiasis. In addition, once the proportion of human with drug-resistant strain produced by drug treatment is larger, the number of human and snails with resistant strain is larger. This is not a good result for drug treatment with praziquantel.

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Cites work

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• Schistosomiasis models with density dependence and age of infection in snail dynamics
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(10)

• The influence of drug treatment on the maintenance of schistosome genetic diversity
• Prevalence-based modeling approach of schistosomiasis: global stability analysis and integrated control assessment
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• A QSPR-like model for multilocus genotype networks of \textit{Fasciola hepatica} in Northwest Spain
• On the role of schistosome mating structure in the maintenance of drug resistant strains
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• Drug resistance or re-emergence? Simulating equine parasites
• Spatiotemporal dynamics of a periodic reaction-advection-diffusion schistosomiasis model with intrinsic and infection incubation periods
• Spatiotemporal dynamics of a reaction-diffusion schistosomiasis model with seasonal and nonlocal transmissions

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