Theoretical analysis of conjugate localization in two-step cancer chemotherapy

DOI10.1007/S002850050195MaRDI QIDQ1961809zbMATH OpenOpenAlexWikidataFDO

Authors Trachette Jackson, Sharon R. Lubkin, J. D. Murray

Publication date 30 January 2000

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s002850050195

zbMATH Keywords

antibody-enzyme conjugatescompartmental approachprodrug administrationtumour geometry

Mathematics Subject Classification ID

Medical applications (general) (92C50) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Numerical methods for partial differential equations, boundary value problems (65N99)

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(12)

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• A mathematical model to study the effects of drug resistance and vasculature on the response of solid tumors to chemotherapy
• Intracellular accumulation and mechanism of action of doxorubicin in a spatio-temporal tumor model
• A computational framework for the administration of 5-aminolevulinic acid before glioblastoma surgery
• MODELLING THE RESPONSE OF VASCULAR TUMOURS TO CHEMOTHERAPY: A MULTISCALE APPROACH
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• A mathematical feasibility argument for the use of aptamers in chemotherapy and imaging

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