Machine learning in drug development: characterizing the effect of 30 drugs on the QT interval using Gaussian process regression, sensitivity analysis, and uncertainty quantification
From MaRDI portal
Publication:1987901
DOI10.1016/j.cma.2019.01.033zbMath1440.62371WikidataQ99629392 ScholiaQ99629392MaRDI QIDQ1987901
Kristen Matsuno, Jiang Yao, Paris Perdikaris, Francisco Sahli Costabal, Ellen Kuhl
Publication date: 16 April 2020
Published in: Computer Methods in Applied Mechanics and Engineering (Search for Journal in Brave)
Full work available at URL: https://doi.org/10.1016/j.cma.2019.01.033
sensitivity analysis; finite element analysis; machine learning; uncertainty quantification; Gaussian process regression; drug development
62G08: Nonparametric regression and quantile regression
62P10: Applications of statistics to biology and medical sciences; meta analysis
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