Modeling cell dynamics in colon and intestinal crypts: the significance of central stem cells in tumorigenesis

DOI10.1007/S11538-018-0457-8MaRDI QIDQ1990141zbMATH OpenOpenAlexWikidataFDO

Authors A. Mahdipour-Shirayeh, Leili Shahriyari

Publication date 24 October 2018

Published in Bulletin of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s11538-018-0457-8

zbMATH Keywords

cancercell migrationfixation probabilitystem cell nichebi-compartmental stochastic modelcentral and border stem cells

Mathematics Subject Classification ID

Cell movement (chemotaxis, etc.) (92C17) Cell biology (92C37)

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Cites work

• A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt
• A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
• Dynamics of Cancer
• Mathematical modeling of monoclonal conversion in the colonic crypt
• Spatial Moran models. II: Cancer initiation in spatially structured tissue

Cited in

(8)

• Model-based phenotypic signatures governing the dynamics of the stem and semi-differentiated cell populations in dysplastic colonic crypts
• Multi-scale modeling of APC and \(\beta \)-catenin regulation in the human colonic crypt
• Modelling the early growth of stem cell tissues
• A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
• A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt
• Mathematical modeling of monoclonal conversion in the colonic crypt
• Estimation of the extent of the cutoff region from the spatial distribution of labelling and mitotic indices of intestinal crypts of a fixed length
• Modeling mechanical control of spindle orientation of intestinal crypt stem cells

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