Multi-scale modeling of APC and -catenin regulation in the human colonic crypt

DOI10.1007/S00285-017-1204-8MaRDI QIDQ1750653zbMATH OpenOpenAlexWikidataFDO

Authors Brooks Emerick, Gilberto Schleiniger, Bruce M. Boman

Publication date 22 May 2018

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s00285-017-1204-8

zbMATH Keywords

APC regulationcolonic cryptcolorectal cancermulti-scale modelwnt pathway

Mathematics Subject Classification ID

Cell movement (chemotaxis, etc.) (92C17) Biochemistry, molecular biology (92C40) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• A kinetic model to study the regulation of \(\beta \)-catenin, APC, and axin in the human colonic crypt
• A multiple timescale analysis of a mathematical model of the Wnt/\(\beta\)-catenin signalling pathway
• A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
• scientific article; zbMATH DE number 2150813 (Why is no real title available?)
• Mathematical modeling of monoclonal conversion in the colonic crypt
• Stability analysis of multi-compartment models for cell production systems

Cited in

(10)

• Estimation of the extent of the cutoff region from the spatial distribution of labelling and mitotic indices of intestinal crypts of a fixed length
• Model-based phenotypic signatures governing the dynamics of the stem and semi-differentiated cell populations in dysplastic colonic crypts
• Mathematical modeling of monoclonal conversion in the colonic crypt
• Modeling cell dynamics in colon and intestinal crypts: the significance of central stem cells in tumorigenesis
• A PDMP model of the epithelial cell turn-over in the intestinal crypt including microbiota-derived regulations
• Elucidating the interactions between the adhesive and transcriptional functions of \(\beta\)-catenin in normal and cancerous cells
• A kinetic model to study the regulation of \(\beta \)-catenin, APC, and axin in the human colonic crypt
• Biomechanical modelling of colorectal crypt budding and fission
• A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
• Mathematical model for simulation of morphological changes associated to crypt fission in the colon

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