Multi-scale modeling of APC and \(\beta \)-catenin regulation in the human colonic crypt

DOI10.1007/s00285-017-1204-8zbMath1390.92051OpenAlexW2781814773WikidataQ47207254 ScholiaQ47207254MaRDI QIDQ1750653

Gilberto Schleiniger, Bruce M. Boman, Brooks Emerick

Publication date: 22 May 2018

Published in: Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL: https://doi.org/10.1007/s00285-017-1204-8

zbMATH Keywords

colorectal cancermulti-scale modelAPC regulationcolonic cryptwnt pathway

Mathematics Subject Classification ID

Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Biochemistry, molecular biology (92C40) Cell movement (chemotaxis, etc.) (92C17)

Related Items

Mathematical model for simulation of morphological changes associated to crypt fission in the colon

Uses Software

• Chaste

Cites Work

• Unnamed Item
• A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
• Mathematical modeling of monoclonal conversion in the colonic crypt
• A multiple timescale analysis of a mathematical model of the Wnt/\(\beta\)-catenin signalling pathway
• A kinetic model to study the regulation of \(\beta \)-catenin, APC, and axin in the human colonic crypt
• Stability analysis of multi-compartment models for cell production systems