Elucidating the interactions between the adhesive and transcriptional functions of -catenin in normal and cancerous cells

DOI10.1016/J.JTBI.2007.01.019MaRDI QIDQ2219677zbMATH OpenOpenAlexWikidataFDO

Authors Ingeborg M. M. Van Leeuwen, H. M. Byrne, Oliver E. Jensen, J. R. King

Publication date 21 January 2021

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1016/j.jtbi.2007.01.019

zbMATH Keywords

adherens junctionAPC mutationcolorectal cancercrypt dynamics

Mathematics Subject Classification ID

Physiology (general) (92C30) Pathology, pathophysiology (92C32) Cell biology (92C37)

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Cites work

• A model for restriction point control of the mammalian cell cycle

Cited in

(14)

• A mathematical model of -catenin dimerization at adherens junctions in polarized epithelial cells
• Switch-like behavior enables Wnt11 concentration specific response during dorso-ventral axis formation in \textit{Xenopus laevis}
• Nucleo-cytoplasmic shuttling of APC can maximize -catenin/TCF concentration
• A multiple timescale analysis of a mathematical model of the Wnt/\(\beta\)-catenin signalling pathway
• A review of spatial computational models for multi-cellular systems, with regard to intestinal crypts and colorectal cancer development
• A kinetic model to study the regulation of \(\beta \)-catenin, APC, and axin in the human colonic crypt
• Revealing the role of SGK1 in the dynamics of medulloblastoma using a mathematical model
• A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
• Combining Intra- and Inter-cellular Dynamics to Investigate Intestinal Homeostasis
• scientific article; zbMATH DE number 7706658 (Why is no real title available?)
• The role of fibroblast-epithelial cross-talk on the distribution of distinct fibroblast phenotypes in the intestinal crypt
• Some results about the structural properties of the Wnt pathway, its steady states and its non-associative commutative algebra
• Chaste: A test-driven approach to software development for biological modelling
• Delay-driven oscillations via axin2 feedback in the Wnt/\(\beta\)-catenin signalling pathway

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