A kinetic model to study the regulation of -catenin, APC, and axin in the human colonic crypt

DOI10.1007/S00285-017-1112-YMaRDI QIDQ2409173zbMATH OpenOpenAlexWikidataFDO

Authors Brooks Emerick, Gilberto Schleiniger, Bruce M. Boman

Publication date 11 October 2017

Published in Journal of Mathematical Biology (Search for Journal in Brave)

Full work available at URL https://doi.org/10.1007/s00285-017-1112-y

zbMATH Keywords

APC regulationcolonic cryptcolorectal cancermultiple timescale analysisWnt pathway

Mathematics Subject Classification ID

Cell biology (92C37) Biochemistry, molecular biology (92C40) Systems biology, networks (92C42) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

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Cites work

• A multiple timescale analysis of a mathematical model of the Wnt/\(\beta\)-catenin signalling pathway
• scientific article; zbMATH DE number 2150813 (Why is no real title available?)

Cited in

(8)

• Switch-like behavior enables Wnt11 concentration specific response during dorso-ventral axis formation in \textit{Xenopus laevis}
• Multi-scale modeling of APC and \(\beta \)-catenin regulation in the human colonic crypt
• Nucleo-cytoplasmic shuttling of APC can maximize -catenin/TCF concentration
• Elucidating the interactions between the adhesive and transcriptional functions of \(\beta\)-catenin in normal and cancerous cells
• A multiple timescale analysis of a mathematical model of the Wnt/\(\beta\)-catenin signalling pathway
• Combining Intra- and Inter-cellular Dynamics to Investigate Intestinal Homeostasis
• Mathematical model for simulation of morphological changes associated to crypt fission in the colon
• Delay-driven oscillations via axin2 feedback in the Wnt/\(\beta\)-catenin signalling pathway

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