A review of spatial computational models for multi-cellular systems, with regard to intestinal crypts and colorectal cancer development
Colon rectal cancers (CRC) are the result of sequences of mutations which lead the intestinal tissue to develop in a carcinoma following a ``progression of observable phenotypes. The actual modeling and simulation of the key biological structures involved in this process are of interest to biologists and physicians and, at the same time, it poses significant challenges from the mathematics and computer science viewpoints. In this report, we give an overview of some mathematical models for cell sorting (a basic phenomenon that underlies several dynamical processes in an organism), intestinal crypt dynamics, and related problems and open questions. In particular, major attention is paid to the survey of so-called ``in-lattice (or grid) models and ``off-lattice (off-grid) models. This paper is the groundwork for future research on semi-automated hypotheses formation and testing about the behavior of the various actors taking part in the adenoma-carcinoma progression, from regulatory processes to cell-cell signaling pathways. Some future directions, e.g., multi-scale modeling and noisy random boolean networks are mentioned.
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- Multiscale modelling of intestinal crypt organization and carcinogenesis
- Homogenization Model for Aberrant Crypt Foci
- A convection-diffusion-shape model for aberrant colonic crypt morphogenesis
- Mathematical model for simulation of morphological changes associated to crypt fission in the colon
- A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt
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- Multiscale modelling and nonlinear simulation of vascular tumour growth
- Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability
- Nonlinear simulation of tumor necrosis, neo-vascularization and tissue invasion via an adaptive finite-element/level-set method
- On the dynamics of random Boolean networks subject to noise: attractors, ergodic sets and cell types
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- Determining the control networks regulating stem cell lineages in colonic crypts
- Model-based phenotypic signatures governing the dynamics of the stem and semi-differentiated cell populations in dysplastic colonic crypts
- Mathematical modeling of monoclonal conversion in the colonic crypt
- A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt
- Buckling of a growing tissue and the emergence of two-dimensional patterns
- A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
- Multiscale modelling of intestinal crypt organization and carcinogenesis
- Combining Intra- and Inter-cellular Dynamics to Investigate Intestinal Homeostasis
- A convection-diffusion-shape model for aberrant colonic crypt morphogenesis
- FBCA, a multiscale modeling framework combining cellular automata and flux balance analysis
- Modeling and Computer Simulation of Viscoelastic Crypt Deformation
- Mathematical model for simulation of morphological changes associated to crypt fission in the colon
- Modeling Spatio-Temporal Dynamics of Metabolic Networks with Cellular Automata and Constraint-Based Methods
- Models, measurement and inference in epithelial tissue dynamics
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