Homogenization Model for Aberrant Crypt Foci
From MaRDI portal
Homogenization in context of PDEs; PDEs in media with periodic structure (35B27) PDEs in connection with fluid mechanics (35Q35) PDEs in connection with biology, chemistry and other natural sciences (35Q92) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Mesh generation, refinement, and adaptive methods for the numerical solution of initial value and initial-boundary value problems involving PDEs (65M50) Finite element, Rayleigh-Ritz and Galerkin methods for initial value and initial-boundary value problems involving PDEs (65M60) Finite element methods applied to problems in fluid mechanics (76M10) Homogenization applied to problems in fluid mechanics (76M50) Cell movement (chemotaxis, etc.) (92C17)
Abstract: Several explanations can be found in the literature about the origin of colorectal cancer. There is however some agreement on the fact that the carcinogenic process is a result of several genetic mutations of normal cells. The colon epithelium is characterized by millions of invaginations, very small cavities, called crypts, where most of the cellular activity occurs. It is consensual in the medical community, that a potential first manifestation of the carcinogenic process, observed in conventional colonoscopy images, is the appearance of Aberrant Crypt Foci (ACF). These are clusters of abnormal crypts, morphologically characterized by an atypical behavior of the cells that populate the crypts. In this work an homogenization model is proposed, for representing the cellular dynamics in the colon epithelium. The goal is to simulate and predict, in silico, the spread and evolution of ACF, as it can be observed in colonoscopy images. By assuming that the colon is an heterogeneous media, exhibiting a periodic distribution of crypts, we start this work by describing a periodic model, that represents the ACF cell-dynamics in a two-dimensional setting. Then, homogenization techniques are applied to this periodic model, to find a simpler model, whose solution symbolizes the averaged behavior of ACF at the tissue level. Some theoretical results concerning the existence of solution of the homogenized model are proven, applying a fixed point theorem. Numerical results showing the convergence of the periodic model to the homogenized model are presented.
Recommendations
- A convection-diffusion-shape model for aberrant colonic crypt morphogenesis
- Mathematical model for simulation of morphological changes associated to crypt fission in the colon
- Biomathematical model for simulating abnormal orifice patterns in colonic crypts
- Modeling and Computer Simulation of Viscoelastic Crypt Deformation
- Multiscale modelling of intestinal crypt organization and carcinogenesis
- A biologically based model for the analysis of premalignant foci of arbitrary shape
- scientific article; zbMATH DE number 850062
- Biomechanical modelling of colorectal crypt budding and fission
- Mathematical modeling of monoclonal conversion in the colonic crypt
- A nonlinear mathematical model of cell turnover, differentiation and tumorigenesis in the intestinal crypt
Cites work
- A computer model of oxygen dynamics in human colon mucosa: implications in normal physiology and early tumor development
- A continuum approach to modelling cell-cell adhesion
- A convection-diffusion-shape model for aberrant colonic crypt morphogenesis
- A hybrid approach to multi-scale modelling of cancer
- A new mathematical model for avascular tumour growth
- A theoretical investigation of the effect of proliferation and adhesion on monoclonal conversion in the colonic crypt
- Asymptotic and numerical homogenization
- Biomechanical modelling of colorectal crypt budding and fission
- Continuous models for cell migration in tissues and applications to cell sorting via differential chemotaxis
- Free boundary problems arising in tumor models
- Homogenization Model for Aberrant Crypt Foci
- scientific article; zbMATH DE number 412120 (Why is no real title available?)
- scientific article; zbMATH DE number 3135303 (Why is no real title available?)
- scientific article; zbMATH DE number 1375522 (Why is no real title available?)
- scientific article; zbMATH DE number 3627589 (Why is no real title available?)
- scientific article; zbMATH DE number 1005391 (Why is no real title available?)
- scientific article; zbMATH DE number 1181255 (Why is no real title available?)
- scientific article; zbMATH DE number 195005 (Why is no real title available?)
- scientific article; zbMATH DE number 3233089 (Why is no real title available?)
- Individual-based models to growth and folding in one-layered tissues: intestinal crypts and early development.
- Mathematical analysis of some multi-dimensional tissue-growth models
- Mathematical modeling of monoclonal conversion in the colonic crypt
- Mathematical Models of Avascular Tumor Growth
- Non-homogeneous media and vibration theory
- Nonlinear simulation of tumor growth
- Nonlinear simulations of solid tumor growth using a mixture model: invasion and branching
- Partial differential equations for self-organization in cellular and developmental biology
- Physiologic parameter estimation using inverse problems
- The general theory of homogenization. A personalized introduction
Cited in
(8)- Density-pressure IBVP: numerical analysis, simulation and cell dynamics in a colonic crypt
- Biomathematical model for simulating abnormal orifice patterns in colonic crypts
- A review of spatial computational models for multi-cellular systems, with regard to intestinal crypts and colorectal cancer development
- Image-driven parameter estimation in absorption-diffusion models of chromoscopy
- A convection-diffusion-shape model for aberrant colonic crypt morphogenesis
- Homogenization Model for Aberrant Crypt Foci
- Modeling and Computer Simulation of Viscoelastic Crypt Deformation
- Mathematical model for simulation of morphological changes associated to crypt fission in the colon
This page was built for publication: Homogenization Model for Aberrant Crypt Foci
Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q5740131)
