Geometric analysis of oscillations in the Frzilator model

DOI10.1016/J.JMAA.2020.124725zbMATH Open1483.34067OpenAlexW3095810208MaRDI QIDQ1995803FDOQ1995803

Authors: Hadi Taghvafard, Hildeberto Jardón-Kojakhmetov, Peter Szmolyan, Ming Cao 

Publication date: 25 February 2021

Published in: Journal of Mathematical Analysis and Applications (Search for Journal in Brave)

Abstract: A biochemical oscillator model, describing developmental stage of myxobacteria, is analyzed mathematically. Observations from numerical simulations show that in a certain range of parameters, the corresponding system of ordinary differential equations displays stable and robust oscillations. In this work, we use geometric singular perturbation theory and blow-up method to prove the existence of a strongly attracting limit cycle. This cycle corresponds to a relaxation oscillation of an auxiliary system, whose singular perturbation nature originates from the small Michaelis-Menten constants of the biochemical model. In addition, we give a detailed description of the structure of the limit cycle, and the timescales along it.

Full work available at URL: https://arxiv.org/abs/1912.00659

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zbMATH Keywords

geometric singular perturbation theorymyxobacteriaslow-fast systemblow-up methodrelaxation oscillations

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Singular perturbations for ordinary differential equations (34E15) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Relaxation oscillations for ordinary differential equations (34C26)

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Cited In (8)

• A geometric analysis of the SIRS epidemiological model on a homogeneous network
• A survey on the blow-up method for fast-slow systems
• Title not available (Why is that?)
• Relaxation oscillations in substrate-depletion oscillators close to the nonsmooth limit
• Geometric singular perturbation analysis of an autocatalator model
• Scaling in singular perturbation problems: blowing up a relaxation oscillator
• Predicting limit cycle boundaries deep inside parameter space of a 2D biochemical nonlinear oscillator using renormalization group
• Parameter-robustness analysis for a biochemical oscillator model describing the social-behaviour transition phase of myxobacteria

Uses Software

• MATCONT

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