Geometric analysis of oscillations in the Frzilator model

DOI10.1016/J.JMAA.2020.124725MaRDI QIDQ1995803zbMATH OpenOpenAlexFDO

Authors Hadi Taghvafard, Hildeberto Jardón-Kojakhmetov, Peter Szmolyan, Ming Cao

Publication date 25 February 2021

Published in Journal of Mathematical Analysis and Applications (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://arxiv.org/abs/1912.00659

zbMATH Keywords

blow-up methodgeometric singular perturbation theorymyxobacteriarelaxation oscillationsslow-fast system

Mathematics Subject Classification ID

Relaxation oscillations for ordinary differential equations (34C26) Qualitative investigation and simulation of ordinary differential equation models (34C60) Singular perturbations for ordinary differential equations (34E15) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45)

Abstract: A biochemical oscillator model, describing developmental stage of myxobacteria, is analyzed mathematically. Observations from numerical simulations show that in a certain range of parameters, the corresponding system of ordinary differential equations displays stable and robust oscillations. In this work, we use geometric singular perturbation theory and blow-up method to prove the existence of a strongly attracting limit cycle. This cycle corresponds to a relaxation oscillation of an auxiliary system, whose singular perturbation nature originates from the small Michaelis-Menten constants of the biochemical model. In addition, we give a detailed description of the structure of the limit cycle, and the timescales along it.

Review text

The authors analyze a biochemical oscillator 3-dimensional model that describes the developmental stage of a myxobacteria. Observations from numerical simulations show that the corresponding ordinary differential system displays stable and robust oscillations. The existence of an attracting limit cycle is proved using geometric singular perturbation theory and blow-up method. It corresponds to a relaxation oscillation of an auxiliary system, whose singular perturbation nature originates from the small Michaelis-Menten constants of the biochemical model.

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Cited in

(10)

• Geometric singular perturbation analysis of an autocatalator model
• Scaling in biochemical kinetics: Dissection of a relaxation oscillator
• A geometric analysis of the SIRS epidemiological model on a homogeneous network
• Parameter-robustness analysis for a biochemical oscillator model describing the social-behaviour transition phase of myxobacteria
• Predicting limit cycle boundaries deep inside parameter space of a 2D biochemical nonlinear oscillator using renormalization group
• A survey on the blow-up method for fast-slow systems
• Scaling in singular perturbation problems: blowing up a relaxation oscillator
• scientific article; zbMATH DE number 6292267 (Why is no real title available?)
• Relaxation oscillations in substrate-depletion oscillators close to the nonsmooth limit
• A geometric analysis of the Bazykin-Berezovskaya predator-prey model with Allee effect in an economic framework

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• MATCONT

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