Geometric analysis of oscillations in the Frzilator model

DOI10.1016/J.JMAA.2020.124725zbMATH Open1483.34067arXiv1912.00659OpenAlexW3095810208MaRDI QIDQ1995803FDOQ1995803

Peter Szmolyan, Hildeberto Jardón-Kojakhmetov, Ming Cao, Hadi Taghvafard

Publication date: 25 February 2021

Published in: Journal of Mathematical Analysis and Applications (Search for Journal in Brave)

Abstract: A biochemical oscillator model, describing developmental stage of myxobacteria, is analyzed mathematically. Observations from numerical simulations show that in a certain range of parameters, the corresponding system of ordinary differential equations displays stable and robust oscillations. In this work, we use geometric singular perturbation theory and blow-up method to prove the existence of a strongly attracting limit cycle. This cycle corresponds to a relaxation oscillation of an auxiliary system, whose singular perturbation nature originates from the small Michaelis-Menten constants of the biochemical model. In addition, we give a detailed description of the structure of the limit cycle, and the timescales along it.

Full work available at URL: https://arxiv.org/abs/1912.00659

Recommendations

• Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle
• Geometric singular perturbation analysis of an autocatalator model
• Multiscale geometry of the Olsen model and non-classical relaxation oscillations
• Relaxation oscillations in substrate-depletion oscillators close to the nonsmooth limit
• Scaling in singular perturbation problems: blowing up a relaxation oscillator

zbMATH Keywords

geometric singular perturbation theorymyxobacteriaslow-fast systemblow-up methodrelaxation oscillations

Mathematics Subject Classification ID

Qualitative investigation and simulation of ordinary differential equation models (34C60) Singular perturbations for ordinary differential equations (34E15) Kinetics in biochemical problems (pharmacokinetics, enzyme kinetics, etc.) (92C45) Relaxation oscillations for ordinary differential equations (34C26)

Cites Work

• Nonlinear oscillations, dynamical systems, and bifurcations of vector fields
• Elements of applied bifurcation theory.
• Title not available (Why is that?)
• MATCONT
• Geometric singular perturbation analysis of an autocatalator model
• Geometric singular perturbation theory for ordinary differential equations
• Relaxation oscillations in \({\mathbb R}^3\)
• Geometric analysis of the Goldbeter minimal model for the embryonic cell cycle
• Extending geometric singular perturbation theory to nonhyperbolic points -- fold and canard points in two dimensions
• Multiple time scale dynamics
• Title not available (Why is that?)
• Canard cycles and center manifolds
• Ordinary differential equations with applications
• Birhythmicity, chaos, and other patterns of temporal self-organization in a multiply regulated biochemical system.
• Local and global analysis of endocrine regulation as a non-cyclic feedback system
• Impulsive model of endocrine regulation with a local continuous feedback
• Parameter-robustness analysis for a biochemical oscillator model describing the social-behaviour transition phase of myxobacteria
• Geometric Singular Perturbation Theory Beyond the Standard Form

Cited In (4)

• A geometric analysis of the SIRS epidemiological model on a homogeneous network
• A survey on the blow-up method for fast-slow systems
• Title not available (Why is that?)
• Geometric singular perturbation analysis of an autocatalator model

Uses Software

• MATCONT

This page was built for publication: Geometric analysis of oscillations in the Frzilator model

Report a bug (only for logged in users!)Click here to report a bug for this page (MaRDI item Q1995803)