Sub-voxel perfusion modeling in terms of coupled 3d-1d problem

DOI10.1007/978-3-319-96415-7_2zbMATH Open1427.65167arXiv1803.04896OpenAlexW2963383520MaRDI QIDQ2008651FDOQ2008651

Authors: Karl Erik Holter, Miroslav Kuchta, Kent-Andre Mardal 

Publication date: 26 November 2019

Abstract: We study perfusion by a multiscale model coupling diffusion in the tissue and diffusion along the one-dimensional segments representing the vasculature. We propose a block-diagonal preconditioner for the model equations and demonstrate its robustness by numerical experiments. We compare our model to a macroscale model by [P. Tofts, Modelling in DCE MRI, 2012].

Full work available at URL: https://arxiv.org/abs/1803.04896

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Mathematics Subject Classification ID

Preconditioners for iterative methods (65F08) Finite difference methods for initial value and initial-boundary value problems involving PDEs (65M06) Numerical methods for eigenvalue problems for boundary value problems involving PDEs (65N25) Finite element, Rayleigh-Ritz and Galerkin methods for boundary value problems involving PDEs (65N30) Physiological flow (92C35) Cell biology (92C37)

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• Mathematics and medicine: how mathematics, modelling and simulations can lead to better diagnosis and treatments
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• ON THE COUPLING OF 1D AND 3D DIFFUSION-REACTION EQUATIONS: APPLICATION TO TISSUE PERFUSION PROBLEMS
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• A singularity removal method for coupled 1D-3D flow models

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