Modeling tissue perfusion in terms of 1d-3d embedded mixed-dimension coupled problems with distributed sources
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Publication:777543
DOI10.1016/J.JCP.2020.109370zbMATH Open1436.76064arXiv1905.03346OpenAlexW3005181186MaRDI QIDQ777543FDOQ777543
Authors: Timo Koch, Martin Schneider, Rainer Helmig, Patrick Jenny 
Publication date: 7 July 2020
Published in: Journal of Computational Physics (Search for Journal in Brave)
Abstract: We present a new method for modeling tissue perfusion on the capillary scale. The microvasculature is represented by a network of one-dimensional vessel segments embedded in the extra-vascular space. Vascular and extra-vascular space exchange fluid over the vessel walls. This exchange is modeled by distributed sources using smooth kernel functions for the extra-vascular domain. It is shown that the proposed method may significantly improve the approximation of the exchange flux, in comparison with existing methods for mixed-dimension embedded problems. Furthermore, the method exhibits better convergence rates of the relevant quantities due to the increased regularity of the extra-vascular pressure solution. Numerical experiments with a vascular network from the rat cortex show that the error in the approximation of the exchange flux for coarse grid resolution may be decreased by a factor of . This may open the way for computing on larger network domains, where a fine grid resolution cannot be achieved in practical simulations due to constraints in computational resources, for example in the context of uncertainty quantification.
Full work available at URL: https://arxiv.org/abs/1905.03346
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Cites Work
- Title not available (Why is that?)
- Title not available (Why is that?)
- Title not available (Why is that?)
- The Identity of Weak and Strong Extensions of Differential Operators
- Well flow models for various numerical methods
- Calculation of well index for nonconventional wells on arbitrary grids
- Finite element approximation of elliptic problems with Dirac measure terms in weighted spaces: applications to one- and three-dimensional coupled problems
- Multiscale modeling of fluid transport in tumors
- On the differentiability of the solutions of linear elliptic differential equations
- Computational models for fluid exchange between microcirculation and tissue interstitium
- Hybrid models for simulating blood flow in microvascular networks
- Multiscale modelling of fluid and drug transport in vascular tumours
- Adaptive hierarchical fracture model for enhanced geothermal systems
- A Discontinuous Galerkin Method to Solve the EEG Forward Problem Using the Subtraction Approach
- On Dirac delta sequences and their generating functions
- Multi-scale homogenization of blood flow in 3-dimensional human cerebral microvascular networks
- Mathematical analysis, finite element approximation and numerical solvers for the interaction of 3D reservoirs with 1D wells
- A local error estimate for the Poisson equation with a line source term
- Efficient finite element formulation for geothermal heating systems. Part I: steady state
- Mathematical modeling, analysis and numerical approximation of second-order elliptic problems with inclusions
- Splitting method for elliptic equations with line sources
- Multiscale homogenization for fluid and drug transport in vascularized malignant tissues
Cited In (18)
- A mixed finite element method for modeling the fluid exchange between microcirculation and tissue interstitium
- A mixed approach to the Poisson problem with line sources
- The modelling error in multi-dimensional time-dependent solute transport models
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- ON THE COUPLING OF 1D AND 3D DIFFUSION-REACTION EQUATIONS: APPLICATION TO TISSUE PERFUSION PROBLEMS
- Nonlinear mixed-dimension model for embedded tubular networks with application to root water uptake
- HAZniCS -- software components for multiphysics problems
- A new computational model for karst conduit flow in carbonate reservoirs including dissolution-collapse breccias
- Modeling and simulation of vascular tumors embedded in evolving capillary networks
- An optimization based 3D-1D coupling strategy for tissue perfusion and chemical transport during tumor-induced angiogenesis
- A PDE-constrained optimization method for 3D-1D coupled problems with discontinuous solutions
- Reduced Lagrange multiplier approach for non-matching coupling of mixed-dimensional domains
- Assembly of multiscale linear PDE operators
- Well-Posedness and Discretization for a Class of Models for Mixed-Dimensional Problems with High-Dimensional Gap
- Projection-based resolved interface 1D-3D mixed-dimension method for embedded tubular network systems
- A new and consistent well model for one-phase flow in anisotropic porous media using a distributed source model
- 3D-1D coupling on non conforming meshes via a three-field optimization based domain decomposition
- Hybrid models for simulating blood flow in microvascular networks
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