Modeling radiotherapy induced normal tissue complications: an overview beyond phenomenological models

DOI10.1155/2016/2796186MaRDI QIDQ2011766zbMATH OpenOpenAlexDBLPWikidataFDO

Authors Marco D'Andrea, Marcello Benassi, Lidia Strigari

Publication date 4 August 2017

Published in Computational \& Mathematical Methods in Medicine (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1155/2016/2796186

zbMATH Keywords

Kallman's Modelnormal tissue complication probabilityradiotherapy

Mathematics Subject Classification ID

Applications of statistics to biology and medical sciences; meta analysis (62P10) Medical applications (general) (92C50)

Review text

Summary: An overview of radiotherapy (RT) induced normal tissue complication probability (NTCP) models is presented. NTCP models based on empirical and mechanistic approaches that describe a specific radiation induced late effect proposed over time for conventional RT are reviewed with particular emphasis on their basic assumptions and related mathematical translation and their weak and strong points.

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Cites work

• Approximating the number of successes in independent trials: binomial versus Poisson
• Binomial approximation to the Poisson binomial distribution: The Krawtchouk expansion
• scientific article; zbMATH DE number 932631 (Why is no real title available?)
• scientific article; zbMATH DE number 3249395 (Why is no real title available?)

Cited in

(4)

• A Bayesian mixture model relating dose to critical organs and functional complication in 3D conformal radiation therapy
• Generalized Monotonic Functional Mixed Models with Application to Modelling Normal Tissue Complications
• A stochastic model for the normal tissue complication probability (NTCP) and applicationss
• Comparison of isoeffect relationships in radiotherapy

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