Tracing the progression of retinitis pigmentosa via photoreceptor interactions
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Publication:2013251
Abstract: Retinitis pigmentosa (RP) is a group of inherited degenerative eye diseases characterized by mutations in the genetic structure of the photoreceptors that leads to the premature death of both rod and cone photoreceptors. Defects in particular genes encoding proteins that are involved in either the photoreceptor structure, phototransduction cascades, or visual cycle are expressed in the rods but ultimately affect both types of cells. RP is "typically" manifested by a steady death of rods followed by a period of stability in which cones survive initially and then inevitably die too. In some RP cases, rods and cones die off simultaneously or even cone death precedes rod death (reverse RP). The mechanisms and factors involved in the development of the different types of RP are not well understood nor have researchers been able to provide more than a limited number of short-term therapies. In this work we trace the progression of RP to complete blindness through each subtype via bifurcation theory. We show that the evolution of RP from one stage to another often requires the failure of multiple components. Our results indicate that a delicate balance between the availability of nutrients and the rates of shedding and renewal of photoreceptors is needed at every stage of RP to halt its progression. This work provides a framework for future physiological investigations potentially leading to long-term targeted multi-facet interventions and therapies dependent on the particular stage and subtype of RP under consideration. The results of this mathematical model may also give insight into the progression of many other degenerative eye diseases involving genetic mutations or secondary photoreceptor death and potential ways to circumvent these diseases.
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Cites work
Cited in
(13)- Mathematical models of retinitis pigmentosa: the oxygen toxicity hypothesis
- The role of RdCVFL in a mathematical model of photoreceptor interactions
- Mathematical models of retinitis pigmentosa: the trophic factor hypothesis
- Bifurcation analysis of a photoreceptor interaction model for retinitis pigmentosa
- Photoreceptor death: spatiotemporal patterns arising from one-hit death kinetics and a diffusible cell death factor
- Mathematical modeling of retinal degeneration: aerobic glycolysis in a single cone
- scientific article; zbMATH DE number 5143722 (Why is no real title available?)
- Optimal control in the treatment of retinitis pigmentosa
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- Spatially-dependent model for rods and cones in the retina
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