The existence and linear stability of periodic solution for a free boundary problem modeling tumor growth with a periodic supply of external nutrients

Abstract: We study a free boundary problem modeling tumor growth with a T-periodic supply

P h i (t)

of external nutrients. The model contains two parameters

m u

and

w i d e t i l d e s i g m a

. We first show that (i) zero radially symmetric solution is globally stable if and only if

w i d e t i l d e s i g m a g e f r a c 1 T i n t_{0}^{T} P h i (t) d t

; (ii) If

w i d e t i l d e s i g m a < f r a c 1 T i n t_{0}^{T} P h i (t) d t

, then there exists a unique radially symmetric positive solution

l e f t (s i g m a_{*} (r, t), p_{*} (r, t), R_{*} (t) i g h t)

with period

T

and it is a global attractor of all positive radially symmetric solutions for all

m u > 0

. These results are a perfect answer to open problems in Bai and Xu [Pac. J. Appl. Math. 2013(5), 217-223]. Then, considering non-radially symmetric perturbations, we prove that there exists a constant

m u_{a s t} > 0

such that

l e f t (s i g m a_{*} (r, t), p_{*} (r, t), R_{*} (t) i g h t)

is linearly stable for

m u < m u_{a s t}

and linearly unstable for

m u > m u_{a s t}

.

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