On the waiting time until coordinated mutations get fixed in regulatory sequences

DOI10.1016/J.JTBI.2021.110657MaRDI QIDQ2031806zbMATH OpenOpenAlexFDO

Authors Günter Bechly, Ann Gauger, Ola G. Hössjer

Publication date 14 June 2021

Published in Journal of Theoretical Biology (Search for Journal in Brave)

Copyright license Creative Commons Attribution 4.0 International

Full work available at URL https://doi.org/10.1016/j.jtbi.2021.110657

zbMATH Keywords

binding sitecontinuous time Markov processcoordinated mutationsMoran modelphase-type distributionregulatory sequencewaiting time

Mathematics Subject Classification ID

Genetics and epigenetics (92D10) Problems related to evolution (92D15)

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Cites work

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• Mathematical population genetics. I: Theoretical introduction.
• Model of effectively neutral mutations in which selective constraint is incorporated
• Mutation-selection networks of cancer initiation: tumor suppressor genes and chromosomal instability
• Phase-type distribution approximations of the waiting time until coordinated mutations get fixed in a population
• Probability Models for DNA Sequence Evolution
• The application of diffusion theory to two population genetic models of Moran
• Waiting for regulatory sequences to appear

Cited in

(7)

• Waiting for \(m\) mutations
• Phase-type distribution approximations of the waiting time until coordinated mutations get fixed in a population
• Waiting for regulatory sequences to appear
• Fixation time for an evolutionary model
• OPTIMAL CONTROL OF GENETIC DIVERSITY IN THE MORAN MODEL WITH POPULATION GROWTH
• Fixation times in differentiation and evolution in the presence of bottlenecks, deserts, and oases
• How is the time for evolution affected by effective population size?

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